Journal: Drug Invention Today

Article Id: JPRS-P col-00004130
Title: The influence of interferon-gamma +874 T/A and interleukin-10 −1082 G/A polymorphisms on culture conversion in Javanese multidrug-resistant tuberculosis patients
Category: Pharmaceutics
Section: Research Article
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    Aim: To determine the influence of gene polymorphisms, especially IFN-γ +874 T/A and IL-10 −1082 G/A to sputum culture conversion of Javanese MDR-TB patients in Indonesia. In this study, the influence of IFN-γ +874 T/A and IL-10 −1082 G/A gene polymorphisms to the sputum culture conversion of Javanese MDR-TB patients was investigated. Method: This study was conducted in patients suspected to have MDR-TB in Moewardi hospital from January 2011 to April 2014. Sputum conversion status, epidemiology, and clinical data of patients were collected. IFN-γ and IL-10 polymorphisms were obtained using Polymerase chain reaction methods. During the study period, 120 from 179 participants that met the inclusion criteria were willing to sign the informed consent. Seven patients dropped out, and six patients died. Result and Discussion: A total of 61 patients had MDR-TB, and 46 patients had TB resistant to rifampicin. Patients with mixed genotypes of +874 A/A IFN-γ and −1082 A/A IL-10 had the longest time of sputum culture conversion (Hazard ratio [HR] = 2.88; 95% confidence interval [CI]: 1.030–8.028; and P = 0.040). Patients with mixed genotypes of +874 T/T IFN-γ and −1082 G/A IL-10 have the fastest time of culture conversion (HR = 0.441; 95% CI: 0.223–0.870; and P = 0.018). Culture conversion of MDR-TB patients was influenced by −1082 A/A IL-10 gene polymorphism (deceleration) and +874 T/T IFN-γ and −1082 G/A IL-10 gene polymorphism (acceleration). Conclusion: The +874 T/T IFN-γ and -1082 A/A IL-10 gene polymorphisms influence culture conversion (deceleration) and the +874 T/T IFN-γ and −1082 G/A IL-10 gene polymorphisms accelerate the culture conversion of Javanese MDR-TB patients.

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    Author(s) Name:

    Harsini Harsini 1,2,3 , Erlina Burhan4 , Afiono Agung Prasetyo1,5 , Suradi Suradi 3,6 , Reviono1,6 , Yusup Subagio Sutanto6 , Dewi Makhabah2 *, N. Ambrosino2,7

    Affiliation(s) Name:

    1 A-Infection, Genomic, Immunology and Cancer Research Group, Sebelas Maret University, Surakarta 57126, Jawa Tengah, Indonesia,

    2 Department of Pulmonology and Respiratory Medicine, Dr. Moewardi General Hospital, Surakarta 57126, Indonesia,

    3 Doctoral Program of Medical Sciences, Faculty of Medicine, Sebelas Maret University, Surakarta 57126, Jawa Tengah, Indonesia,

    4 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia,

    5 Center of Biotechnology and Biodiversity Research and Development, Sebelas Maret University, Surakarta 57126, Jawa Tengah, Indonesia,

    6 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta 57126, Jawa Tengah, Indonesia, 7 Volttera Ricerche, Help Avoid, Volterra, Italy

    *Corresponding author: Dewi Makhabah, Department of Pulmonology and Respiratory Medicine, Dr. Moewardi General Hospital, Surakarta 57126, Indonesia.

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    Author:

    Harsini Harsini 1,2,3 , Erlina Burhan4 , Afiono Agung Prasetyo1,5 , Suradi Suradi 3,6 , Reviono1,6 , Yusup Subagio Sutanto6 , Dewi Makhabah2 *, N. Ambrosino2,7

    Title:The influence of interferon-gamma +874 T/A and interleukin-10 −1082 G/A polymorphisms on culture conversion in Javanese multidrug-resistant tuberculosis patients
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2440-2445)
  • Experimental Methods Keywords

    Methodology:Culture conversion, Interferon-gamma, Interleukin-10, Multidrug-resistant tuberculosis, Polymorphisms
    Research Materials:multidrug-resistant tuberculosis patients

Keywords

Culture conversion Interferon-gamma Interleukin-10 Multidrug-resistant tuberculosis Polymorphisms

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