Journal: Drug Invention Today

Article Id: JPRS-P col-00004132
Title: Comparison of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in Tenon’s capsule tissue at superior fornix, inferior fornix, and interpalpebral area in socket contracture
Category: Pharmaceutics
Section: Research Article
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    Background: This study aims to observe the difference between the expression of matrix metalloproteinase (MMP)-2 and MMP-9 in Tenon’s capsule tissue from superior fornix, inferior fornix, and interpalpebral area in socket contracture. Methods: This was an analytic observational study with cross-sectional approach. Expression of MMP-2 and MMP-9 was measured with immunohistochemistry staining. Data were analyzed with Kruskal–Wallis test and continued with Mann– Whitney U-test and Spearman correlation tests. Results: The subjects were three socket contracture patients which two subjects with Grade 4 and one subject with Grade 5. Subjects were about 42-year-old men and women. Tenon’s capsule from inferior fornix showed the highest expression of MMP-2 (P = 0.018). Meanwhile, there was no significant difference in MMP-9 expression in these three areas (P = 0.212). There was no correlation between the expression of MMP-2 and MMP- 9 (P = 0.978). Conclusion: There was a significant difference in MMP-2 in Tenon’s capsule tissue from superior fornix, inferior fornix, and interpalpebral area.

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  • About the authors and Affiliations

    Author(s) Name:

    Debby Shintiyadewi 1 *, Harir Rahmaniah1 , Hidayat Sujuti 2

    Affiliation(s) Name:

    1 Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia,

    2 Department of Biochemistry and Biomolecular, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

    *Corresponding author:Debby Shintiyadewi, Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Dr. Saiful Anwar General Hospital, Malang 65145, East Java, Indonesia.

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    Author:

    Debby Shintiyadewi 1 *, Harir Rahmaniah1 , Hidayat Sujuti 2
    Title:Comparison of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in Tenon’s capsule tissue at superior fornix, inferior fornix, and interpalpebral area in socket contracture
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (0-0)

  • Experimental Methods Keywords

    Methodology:Immunohistochemistry, Kruskal–Wallis test, Whitney U-test and Spearman correlation tests
    Research Materials:42-year-old men and women

Keywords

Immunohistochemistry Inferior fornix Interpalpebral Matrix metalloproteinase-2 Matrix metalloproteinase-9 Socket contracture Superior fornix

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