Journal: Drug Invention Today

Article Id: JPRS-P col-00004133
Title: The role of immunoglobulin M anti-phenolic glycolipid-1 and matrix metalloproteinase-9 levels in blood serum in peripheral nerve damage of multibacillary leprosy
Category: Pharmaceutics
Section: Research Article
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    Background: Schwann cells can also induce upregulation of matrix metalloproteinase (MMP)-9 productions, which is thought to be one of the cellular mediators of nerve damage from leprosy, especially in paucibacillary (PB) leprosy. Objective: This study aimed to analyze the roles of immunoglobulin M (IgM) anti-phenolic-glycolipid 1 (PGL-1) and MMP- 9 in peripheral nerve damage in multibacillary (MB) leprosy. Methods: The levels of IgM anti-PGL-1 and MMP-9 were examined by ELISA technique, while laboratory examination of the skin incision was done to determine the bacterial index (BI) and the morphological index (MI) after Ziehl–Neelsen staining. Results: Serum IgM anti-PGL-1 and MMP-9 levels were significantly different between leprosy patients and household contacts (P < 0.005). There was a significant difference in serum IgM anti-PGL-1 levels between leprosy patients with BI values <3 and ≥3 (P < 0.005), but no significant difference was found in serum MMP-9 levels between leprosy patients with BI scores of <3 and ≥3. IgM anti-PGL-1 (P = 0.006) was statistically significant as a variable that was more responsible for peripheral nerve damage in MB leprosy than MMP-9 (P = 0.042). Conclusion: IgM PGL-1 was more important than MMP-9 in causing peripheral nerve damage in MB leprosy.

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    Author(s) Name:

    Fitriyanti 1 *, Yanwirasti 1 , Jamsari 2 , Raden Pamudji 3

    Affiliation(s) Name:

    1 Department of Doctoral Program Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia,

    2 Department of Biotechnology, Faculty of Agriculture, Andalas University, Padang, Indonesia,

    3 Department of Dermatology and Venereology, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia

    *Corresponding author: Fitriyanti, Department of Doctoral Program Biomedical Science, Faculty of Medicine, Andalas University, Perintis Kemerdekaan Street No 94 Jati, Padang, West Sumatera, 25127 Indonesia.

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    Author:

    Fitriyanti 1 *, Yanwirasti 1 , Jamsari 2 , Raden Pamudji 3

    Title:The role of immunoglobulin M anti-phenolic glycolipid-1 and matrix metalloproteinase-9 levels in blood serum in peripheral nerve damage of multibacillary leprosy
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2452-2457)
  • Experimental Methods Keywords

    Methodology:Multibacillary leprosy, Mycobacterium leprae, Peripheral nerves
    Research Materials:immunoglobulin M (IgM

Keywords

Matrix metalloproteinase Multibacillary leprosy Mycobacterium leprae Peripheral nerves

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