Journal: Drug Invention Today

Article Id: JPRS-P col-00004140
Title: Actions of riluzole on GluR5 subunit of kainate receptors in rat migraine model
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Introduction: Migraine a major public health problem occurring due to the consequences of serial multi-pathophysiological changes in the trigeminal nerve ganglion leading to imbalance in the excitation and inhibition. The glutamate is the major excitatory neurotransmitter in the central nervous system causing excitotoxicity to the sensory neurons leading to sensitization and nociception. Materials and Methods: The present study was done to determine the effects of riluzole on the GluR5 subunits of kainate receptors after inducing migraine. The rats were treated with riluzole (6 mg/kg) after inducing migraine with nitroglycerin 10 mg/kg. Results and Conclusions: The nitroglycerin treated rats showed intense staining for GluR5 subunits and there was a decrease in its expression after riluzole treatment. This study concludes that the GluR5 subunits are upregulated during migraine and riluzole can be used to control those upregulation by its neuroprotectant property.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    P. K. Sankaran1,2 *, Gunapriya Raghunath2 , Jeeva Priya3 , Maria Francis Yuvaraj 2 , T. Siva4 , M. Kumaresan2 , G. Karthikeyan2 , A. Priyadharshini 2

    Affiliation(s) Name:

    1 Department of Anatomy, AIIMS, Mangalagiri, Andhra Pradesh, India,

    2 Department of Anatomy, Saveetha Medical College and Research Institute, Chennai, Tamil Nadu, India,

    3 Department of Anatomy, Madha Medical College, Chennai, Tamil Nadu, India,

    4 Department of Anatomy, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. P. K. Sankaran, Department of Anatomy, AIIMS, Mangalagiri, Andhra Pradesh, India

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    P. K. Sankaran1,2 *, Gunapriya Raghunath2 , Jeeva Priya3 , Maria Francis Yuvaraj 2 , T. Siva4 , M. Kumaresan2 , G. Karthikeyan2 , A. Priyadharshini 2

    Title:Actions of riluzole on GluR5 subunit of kainate receptors in rat migraine model
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2481-2484)
  • Experimental Methods Keywords

    Methodology:migraine model
    Research Materials:riluzole , GluR5

Keywords

GluR5 Glutamate Headache Kainate Migraine Riluzole

Our Services

Most Downloaded List