Journal: Drug Invention Today
Title: Evaluation of the antimicrobial efficacy and phytochemical constituents of the extracts of Andrographis paniculata against drug-resistant bacterial pathogens
Category: Pharmaceutics
Section: Research Article
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Abstract
Background: The emergence of drug-resistant bacteria has led to the search for newer plant-derived antimicrobial agents with lesser side effects. Andrographis paniculata (Nilavembu), the chief ingredient nilavembu kudineer has been successfully used in the treatment of dengue fever outbreak in India. Hence, this study was proposed to examine the antibacterial activity of A. paniculata against multidrug-resistant isolates of Gram-positive cocci (vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus [MRSA]) and Gram-negative bacilli (extended-spectrum beta- lactamase [ESBL]-producing Escherichia coli and Pseudomonas aeruginosa). Standard strains, ATCC 25922 E. coli, ATCC 25923 S. aureus, ATCC 27853 P. aeruginosa, and ATCC 29212 E. faecalis were used as controls. Methods: Extracts such as methanol, acetone, chloroform, and ethanol of A. paniculata (leaf) were prepared by cold percolation method. Agar well diffusion method was employed to assess the antibacterial activity. Minimum inhibitory concentration was determined using microbroth dilution method. Results: Results showed methanol extract exhibited maximum antibacterial activity against clinical and control strains. Phytochemical analysis of the methanol extract has confirmed the presence of an array of bioactive compounds. Conclusion: Methanolic extract of A. paniculata could serve as a potential herbal alternative in the management of infections caused by VRE and MRSA, while the ethanolic extract of A. paniculata could be used in the effective therapeutic management of ESBL-positive P. aeruginosa.
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About the authors and Affiliations
Author(s) Name: Thirunavukkarasu Umaarasu1,2 , Kesavaram Padmavathy1 *, Dharmalingam Thirunavukkarasu3 , S. V. Rajesh4 , Jayamathi Govindaraj5 , Gnanendra Shanmugam6
Affiliation(s) Name: 1 Department of Microbiology, Research Laboratory for Oral and Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,
2 Department of Microbiology, Vivekanandha Dental College, Tiruchengode, Tamil Nadu, India,
3 Department of Microbiology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India,
4 Department of Botany, Ramakrishna Mission Vivekanandha College, Mylapore, Chennai, Tamil Nadu, India,
5 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India,
6 Department of Biotechnology, Yeungnam University, Gyeongsan, South Korea
*Corresponding author: Kesavaram Padmavathy, Department of Microbiology, Research Laboratory for Oral and Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
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Author: Thirunavukkarasu Umaarasu1,2 , Kesavaram Padmavathy1 *, Dharmalingam Thirunavukkarasu3 , S. V. Rajesh4 , Jayamathi Govindaraj5 , Gnanendra Shanmugam6
Title: Evaluation of the antimicrobial efficacy and phytochemical constituents of the extracts of Andrographis paniculata against drug-resistant bacterial pathogens Journal: Drug Invention Today Vol(issue): 11 (October ) Year: 2019 Page No: (2485-2489) -
Experimental Methods Keywords
Methodology: Antibacterial efficacy, Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Vancomycin-resistant Enterococci Research Materials: Andrographis paniculata
Keywords
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