Journal: Drug Invention Today

Article Id: JPRS-P col-00004212
Title: Immunological marker of human papillomavirus type 6 infection in epithelial ovarian tumor before and after paclitaxel drug treatment in Al-Najaf Governorate, Iraq
Category: Pharmaceutics
Section: Research Article
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    Background: Ovarian cancer is the most common type of female cancer. The etiology of ovarian cancer is still unclear. Infection with different microbes may induce carcinogenesis. Chronic inflammation caused by infection may play a role in carcinogenesis, progression, and metastasis. Materials and Methods: A total of21 patients with different types of malignant epithelial tumor included in this study. Serum samples from patients were collected from patients diagnosed as epithelial ovarian tumor. All the patients had provided their medical history and had undergone clinical and ultrasound examination. The average age of this group was 45.8 years and the range was 10–80 years. The blood sample was dispensed in a plain tube and left for 20 min at room temperature (20–25°C) for clotting. Then, it was centrifuged to collect serum. The serum was divided into aliquots (0.3 ml) and stored in the freezer (−20°C) until use for the measurement of interleukin-6 and tumor necrosis factor (TNF). Results: The study showed that ovarian cancer usually occurred in patients aged more than 50 years 15 (71%) ovarian cancer patients lived in urban areas 12 (57%), while in rural areas 9 (42%). High percentage of patient with ovarian cancer were in stage III. Six cases of 9 (Stage III) malignant surface epithelial tumors were human papillomavirus (HPV) positive which is statistically significant. A total of ovarian carcinomas were categorized as TNF-α negative 5.7 ± 1.6 and 28.3 ± 3.1 as TNF-α positive. Both parameters showed significant differences. Conclusion: This study may raise the suspicion of possible role of HPV6 in pathogenesis of ovarian tumors and the benefit of immunological markers in progression of the disease which need further works to prove this role.

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    Author(s) Name:

    Maitham Ghaly Yousif 1 *, Ataa K. Al-Shamari 2 , Alaa Mohammed Sadiq3

    Affiliation(s) Name:

    1 Department of Biology, College of Science, University of Al-Qadisiyah, Al Diwaniyah, Iraq,

    2 Department of Pathological Analysis, Al-Mustaqbal University College, Hillah, Iraq,

    3 College of Medicine, Kufa University, Kufa, Iraq

    *Corresponding author: Maitham Ghaly Yousif, Department of Biology, College of Science University of Al-Qadisiyah, Iraq.

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    Author:

    Maitham Ghaly Yousif 1 *, Ataa K. Al-Shamari 2 , Alaa Mohammed Sadiq3

    Title:Immunological marker of human papillomavirus type 6 infection in epithelial ovarian tumor before and after paclitaxel drug treatment in Al-Najaf Governorate, Iraq
    Journal:Drug Invention Today
    Vol(issue):12 (October)
    Year:2019
    Page No: (2225-2228)
  • Experimental Methods Keywords

    Methodology:21 patients with different types of malignant epithelial tumor i
    Research Materials:paclitaxel drug

Keywords

Human papillomavirus-6 Interleukin-6 Ovarian tumor Paclitaxel Tumor necrosis factor-alpha

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