Journal: Drug Invention Today

Article Id: JPRS-P col-00004254
Title: Diagnostic value of hematological parameters in acute appendicitis
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of the study was to investigate the diagnostic value of the mean platelet volume (MPV) and platelet distribution width (PDW) in acute appendicitis. Materials and Methods: This is a retrospective, case-controlled study which compared 100 patients with acute appendicitis (study group) and 100 healthy individuals (control group). The age, gender, white blood cell (WBC) count, neutrophil percentage, MPV, and PDW values from blood samples were compared among the groups. Statistical analyses were performed using SPSS for Windows software. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were calculated. Results: The mean ages of patients were 27.4 ± 10.44 of the study group and 39.28 ± 13.21 for control group. Age and gender were not significantly different among the groups. Whereas WBC count and neutrophil percentage were higher in the study group compared to control group and MPV was found to be lower in study group patients, and PDW was not significantly different. The diagnostic sensitivity, specificity, and diagnostic accuracy were 94.7%, 77.4%, and 84% for WBC count, 81.7%, 84.4%, and 83% for neutrophil percentage, 85.1%, 70.6%, and 76% for MPV, and 50%, 50%, and 50% for PDW, respectively. The highest diagnostic accuracy detected was for WBC count followed by neutrophil percentage and MPV between study group and control group with P < 0.005. Conclusion: Considering the MPV decrease along with the WBC count and neutrophil percentage elevation would be beneficial in patients with suspicion of acute appendicitis.

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    Author(s) Name:

    D. Raga Priya, Gayathri Devi Thanigaimani*, Hemalatha Ganapathy

    Affiliation(s) Name:

    Department of  Pathology, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Gayathri Devi Thanigaimani, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

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    Author:

    D. Raga Priya, Gayathri Devi Thanigaimani*, Hemalatha Ganapathy

    Title:Diagnostic value of hematological parameters in acute appendicitis
    Journal:Drug Invention Today
    Vol(issue):12 (October)
    Year:2019
    Page No: (2402-2406)
  • Experimental Methods Keywords

    Methodology:hematological parameters, Diagnosis, Mean platelet volume
    Research Materials: Appendicitis

Keywords

Appendicitis Diagnosis Mean platelet volume

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