Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004302
Title: Synergistic antibacterial activity of mangiferin with antibiotics against Staphylococcus aureus
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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  • Abstract

    Aim: The present study aimed to evaluate the synergistic effect of mangiferin with antibiotics against Staphylococcus aureus. Materials and Methods: Mangiferin was isolated from Mangifera indica and tested for its synergistic activity with eight standard antibiotics against S. aureus using disc diffusion method. Results and Discussion: The results showed that 4 mg/disc of mangiferin exerted synergistic antibacterial effect on S. aureus when used in combination with four standard antibiotics. Combination with nalidixic acid, ampicillin, tetracycline, and sulfamethoxazole/trimethoprim resulted in fold increase in area 69.00%, 21.37%, 16.16%, and 4.16%, respectively. At the same time, there is no synergetic antibacterial effect observed with other tested antibiotics against S. aureus. Furthermore, there is no antagonistic antibacterial effect for the tested antibiotics. Conclusion: The results demonstrated that mangiferin is a safe natural product which can potentiate antibacterial effect of some antibiotics suggesting good potential for combination therapy against S. aureus.

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    Author(s) Name:

    Nurul Azima Mazlan1 , Shazalyana Azman2 , Nurin Fatini Ghazali 1 , Puteri Zarith Sofea Yusri 1 , Hikmah Mohd Idi 1 , Masitah Ismail 3 , Mahendran Sekar1 *

    Affiliation(s) Name:

    1 Department of  Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia,

    2 Bioengineering and Technology Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology, Alor Gajah, Melaka, Malaysia,

    3 Department of Preclinical, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia

    *Corresponding author: Dr. Mahendran Sekar, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, 30450 Ipoh, Malaysia.

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    Author:

    Nurul Azima Mazlan1 , Shazalyana Azman2 , Nurin Fatini Ghazali 1 , Puteri Zarith Sofea Yusri 1 , Hikmah Mohd Idi 1 , Masitah Ismail 3 , Mahendran Sekar1 *
    Title:Synergistic antibacterial activity of mangiferin with antibiotics against Staphylococcus aureus
    Journal:Drug Invention Today
    Vol(issue):12 (November [ Special Issue 1])
    Year:2019
    Page No: (14-17)

  • Experimental Methods Keywords

    Methodology:antibacterial activity
    Research Materials:Mangiferin with antibiotics

Keywords

Antibacterial Disc diffusion method Mangiferin Staphylococcus aureus Synergism

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