Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004357
Title: Distal renal tubular acidosis secondary to vesicoureteral reflex: A case report in a 14-year-old girl
Category: Pharmacology
Section: Case Studies
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    Vesicoureteric reflux (VUR) is the most common congenital anomaly of the urinary tract that occurs in 30–50% of children presenting with recurrent urinary tract infections. Long-standing untreated VUR results in renal scarring and hydronephrotic change ultimately leading to chronic renal failure and arterial hypertension. However, it may also result in diffuse tubulopathy compromising the concentrating capacity of tubules and urinary acidification defects. Renal tubular dysfunction should be considered in all children with VUR presenting with failure to thrive, rickets, bony deformity/pain, hypokalemia, and metabolic acidosis. We report such a case of a 14-year-old girl who presented with rickets, failure to gain weight and height, bony pains, and muscle weakness with a history of VUR. On investigation, she was found to have normal anion gap metabolic acidosis with hypokalemia suggestive of distal renal tubular acidosis. She responded well to oral alkali and potassium replacement therapy.

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    Author(s) Name:

    R. Raghuram*, R. Ramya, Shanthi Ramesh, S. Sundari

    Affiliation(s) Name:

    Department of Paediatrics, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. R. Raghuram, Department of Paediatrics, Sree Balaji Medical College and Hospital, 7 Works Road, New Colony, Chromepet, Chennai - 600 044, Tamil Nadu, India

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    Author:

    R. Raghuram*, R. Ramya, Shanthi Ramesh, S. Sundari

    Title:Distal renal tubular acidosis secondary to vesicoureteral reflex: A case report in a 14-year-old girl
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2780-2782)
  • Experimental Methods Keywords

    Methodology:A case report, Distal renal tubular acidosis, Nephrocalcinosis, Vesicoureteral reflex
    Research Materials:a 14-year-old girl

Keywords

Distal renal tubular acidosis Nephrocalcinosis Vesicoureteral reflex

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