Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004361
Title: Evaluation of in vitro antidiabetic effect and phytochemical screening of some wild mushroom extracts isolated in Basrah, Iraq
Category: Pharmacology
Section: Research Article
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    Background: Diabetes mellitus is a cardiovascular risk associated with chronic hyperglycemia in the blood; it is considered a modern-day epidemic and is really known as global public health. The aim of the present study was to assess the antidiabetic activity of some wild mushroom extracts which grown in Basrah Province. Materials and Methods: Ethanolic extracts were prepared from mushrooms fruiting bodies and their phytochemical analysis was determined. However, the ability of mushroom extracts to reduce the level of blood glucose in vitro was evaluated through α-amylase inhibition assay and glucose diffusion method, as well as, the detection of crude extracts cytotoxicity was examined. Results: The results were revealed the isolation of 12 species of mushrooms due to five genera including Agaricus spp. (four species), Coprinus spp. (two species), Panaeolus spp. (two species), Psathyrella spp. (three species), and Scleroderma sp., while the phytochemical assay was showed the dominance of polysaccharides, saponins, and tannins. Since the highest effect of α-amylase inhibition was seen at 500 µg for Agaricus sp. 1 and Coprinus sp. extracts (91%) followed by Scleroderma sp. extract (90%). Conclusion: The value of index for impaired glucose distribution glucose diffusion retardation index was reached after 3 h for all mushroom extracts, whereas the result was showed increasing value with time and concentration. Mushroom extracts were not revealed cytotoxic effect at doses of 5, 10, 50, 100, and 200 µg except Psathyrella sp. 2 and Panaeolus sp. 2 extracts that seen cytotoxicity at doses of 200 and 100 µg, respectively.

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    Author(s) Name:

    Sara A. Maktoof, Inaam M. N. Alrubayae*, Nasir A. Almansorii

    Affiliation(s) Name:

    Department of Biology, Science College, Basrah University, Basrah, Iraq

    *Corresponding author: Inaam M. N. Alrubayae, Department of Biology, Science College, Basrah University, Iraq.

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    Author:

    Sara A. Maktoof, Inaam M. N. Alrubayae*, Nasir A. Almansorii

    Title:Evaluation of in vitro antidiabetic effect and phytochemical screening of some wild mushroom extracts isolated in Basrah, Iraq
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2797-2803)
  • Experimental Methods Keywords

    Methodology:Antidiabetic, Cytotoxicity Activity
    Research Materials:wild mushroom extracts

Keywords

Antidiabetic Cytotoxicity Ethanolic extracts Mushrooms

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