Journal: Drug Invention Today

Article Id: JPRS-P col-00004362
Title: Design and development of mucoadhesive buccal patches of chlorzoxazone
Category: Pharmaceutics
Section: Research Article
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    Aim and Objective: The main purpose of this study was to formulate and evaluate chlorzoxazone mucoadhesive buccal patches, to increase therapeutic efficacy, better bioavailability, and reduce the side effect, and to provide controlled release of drug and improve patient compliance. Chlorzoxazone is used in the treatment of muscle spasm/pain and helps in relaxing the muscles. Materials and Methods: Buccal films of chlorzoxazone were prepared by solvent casting technique using film-forming mucoadhesive polymers such as hydroxypropyl methylcellulose and ethyl cellulose with different concentrations. Five different formulations were prepared and evaluated with respect to patch thickness, surface pH, folding endurance, drug content uniformity, swelling index, determination of moisture and moisture absorption, and in vitro release study. Compatibility study was carried out by Fourier transform infrared (FT-IR) spectral analysis. Results and Discussion: FT-IR study confirmed the absence of any drug/drug-polymer excipient interaction. All the prepared formulations were evaluated. The formulation F2 showed good drug content compared other formulations and in in vitro release studies of formulation F2 show better drug release for a period of 4.5 h. F2 shows decrease in drug release with an increase in amount of polymer. Therefore, F2 was selected as best formulation. Conclusion: The above study concluded that possibilities of the making of mucoadhesive drug delivery system for chlorzoxazone which will be more efficacious and also having satisfactory sustained release profile which may provide and increased therapeutic efficacy.

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    Author(s) Name:

    E. Padhma Priya, Ashwin Karthik, Illakiya Azhaki, K. Meenakashi, S. Jeganath*, B. Nitish, Digvijay Jena

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. S. Jeganath, Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Vels University, Pallavaram, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    E. Padhma Priya, Ashwin Karthik, Illakiya Azhaki, K. Meenakashi, S. Jeganath*, B. Nitish, Digvijay Jena

    Title:Design and development of mucoadhesive buccal patches of chlorzoxazone
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2804-2809)
  • Experimental Methods Keywords

    Methodology:Design and development, mucoadhesive buccal patches
    Research Materials:chlorzoxazone

Keywords

Buccal patches Chlorzoxazone Hydroxypropyl methylcellulose

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