Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004364
Title: Evaluation of cardiovascular disease risk and renal function in women with uterine fibroids
Category: Pharmacology
Section: Research Article
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  • Abstract

    Objective: Recent studies have found a positive association of uterine fibroids with hypertension. However, other cardiovascular disease (CVD) risk factors and renal function have not been evaluated. Accordingly, we aimed to investigate the CVD risk factors and renal function in women with uterine fibroids. Materials and Methods: A total of 77 reproductive- aged women (18–60 years) were enrolled in the study and were divided into case group (n = 37) women with uterine fibroids and control group (n = 40) without fibroids. The following clinical and demographic parameters such as age, body mass index (BMI), hypertension, diabetes mellitus, hyperlipidemia, and further renal function markers (urea and creatinine) were recorded at baseline and 3-month follow-up period and compared between the groups. Results: Comparison of CVD risk factors between women with and without uterine fibroids revealed that the presence of hypertension (29 [78%] vs. 8 [20%], P = 0.003), diabetes mellitus (5 [13.5%] vs. 1 [2.5%], P = 0.04), and hyperlipidemia (4 [10.8%] vs. 2 [5%], P = 0.03) was significantly higher in patients with uterine fibroids than in the control group. Conclusion: Uterine fibroids were associated with a significant elevated risk of hypertension, diabetes mellitus, and hyperlipidemia.

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    Author(s) Name:

    R. Alice1 , P. Shanmugasundaram2 *

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. P. Shanmugasundaram, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, P. V. Vaithiyalingam Road, Velan Nagar, Krishnapuram, Pallavaram, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    R. Alice1 , P. Shanmugasundaram2 *

    Title:Evaluation of cardiovascular disease risk and renal function in women with uterine fibroids
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2814-2817)
  • Experimental Methods Keywords

    Methodology:Evaluation of cardiovascular disease risk and renal function, clinical and demographic parameters such as age, body mass index (BMI), hypertension, diabetes mellitus, hyperlipidemia, and further ren
    Research Materials: 77 women

Keywords

Cardiovascular disease risk Hypertension Renal function Uterine fibroids

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