Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004365
Title: Biomedical potential of hesperidin against methotrexate induce hepatotoxicity
Category: Pharmacology
Section: Research Article
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    Introduction: Methotrexate (MTX) is an antiproliferative agent and is one of the most widely used anticancer drugs. Cytotoxic effect of MTX also affects the vital orangs, one of the well-known toxicity caused by MTX chemotherapy is liver damage, and it induces liver cirrhosis and fibrosis. Hesperidin is an antioxidant which acts as active flavanone glycoside found in citrus whole fruit and peel also a byproduct of citrus. Materials and Methods: Normal rats given vehicle for 7 days are served as vehicle control. Rats were given intraperitoneal injection of MTX (20 mg/kg body weight) 24 h before the treatment. Rats were given pretreatment with hesperidin orally for 7 days. Rats were given pretreatment with hesperidin before the induction of hepatic damage by administration of MTX. At the end of the experimental period, the animals were sacrificed by cervical decapitation. The blood and liver tissue was used to assess the biochemical change. Results: The activities of marker enzymes alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyltranspeptidase were found to be elevated in MTX-induced hepatotoxicity. Decline in the activities of membrane-bound phosphatase found during MTX-induced liver damage was reverted back to normal when pretreated with hesperidin, indicating the membrane stabilizing potential of hesperidin. Histopathological observations in MTX induced and hesperidin pretreated rats reveal the protective nature of the hesperidin against MTX-induced liver damage and further support the hepatoprotective potential of hesperidin. Conclusion: The above result concluded that hesperidin has potential clinical applications in MTX-induced liver damage.

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    Author(s) Name:

    I. Somasundaram*

    Affiliation(s) Name:

    Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    I. Somasundaram*

    Title:Biomedical potential of hesperidin against methotrexate induce hepatotoxicity
    Journal:Drug Invention Today
    Vol(issue):12 (October)
    Year:2019
    Page No: (2818-2824)
  • Experimental Methods Keywords

    Methodology:Histopathology, Liver marker enzymes, Biomedical potential
    Research Materials: Hesperidin

Keywords

Hesperidin Histopathology Liver marker enzymes Methotrexate

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