Journal: Drug Invention Today

Article Id: JPRS-P col-00004367
Title: Mimosa pudica and Limonia acidissima gum loaded mucoadhesive microspheres of glipizide for the treatment of type 2 diabetes mellitus: In vitro and in vivo evaluation
Category: Pharmaceutics
Section: Research Article
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    Aim: The purpose of this present study is to prepare, characterize, and in vivo evaluation of mucoadhesive microspheres of glipizide for prolongation of gastric retention in animal stomach, thereby increase the bioavailability of those drugs having narrow therapeutic index. Materials and Methods: Mucoadhesive microspheres were prepared by ionic gelation method using sodium alginate along with Carbopol 934P (Car934P), Mimosa pudica, and Limonia acidissima gum mucilage as gel forming and mucoadhesive, respectively. Prepared dosage form characterized by their parameters such as particle size, micrometric properties, drug entrapment efficiency, swelling index, mucoadhesion capacity, in vitro drug release, and in vivo studies to confirm their suitability to gastroretentive drug delivery systems. Results: Differential scanning calorimetry (DSC) study was confirmed that there was no chemical interaction between the drug and polymers. The flow properties were found to be excellent and in vitro drug release study was performed in pH 1.2 HCl buffer for 12 h time duration. It was observed that formulation F3 showed optimum drug release (96.76%) for 12 h and was retained in rabbit stomach mucosa of rabbit for more than 8 h during X-ray study. It was proved that the drug release from the microspheres followed zero-order kinetics and mechanism was found to be non-Fickian transport. Conclusion: Based on the result, it was concluded that natural polymers have promising mucoadhesive in rabbit stomach like synthetic polymer (Car934P) and formulation F3 showed better retardation effect than the other formulations and it was concluded that prepared dosage form has better mucoadhesion and bioavailability.

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    Author(s) Name:

    R. Ananthakumar1 , S. Sathesh Kumar1 , K. Chitra2 *

    Affiliation(s) Name:

    1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2 Department of Pharmaceutical Chemistry, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

    *Corresponding author: K. Chitra, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), No.1 Ramachandra Nagar, Porur, Chennai - 600 116, Tamil Nadu, India.

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    Author:

    R. Ananthakumar1 , S. Sathesh Kumar1 , K. Chitra2 *

    Title:Mimosa pudica and Limonia acidissima gum loaded mucoadhesive microspheres of glipizide for the treatment of type 2 diabetes mellitus: In vitro and in vivo evaluation
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2831-2835)
  • Experimental Methods Keywords

    Methodology:Diabetes, Mucoadhesive microspheres
    Research Materials: Glipizide, Limonia acidissima, Mimosa pudica

Keywords

Diabetes Glipizide Limonia acidissima Mimosa pudica Mucoadhesive microspheres

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