Journal: Drug Invention Today

Article Id: JPRS-DFP-00004368
Title: Formulation and evaluation of herbal gel from the ethanolic extract of the stem bark of Bauhinia variegata Linn. for antimicrobial activity
Category: Drugs from Plants
Section: Research Article
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    Aim: The study was conceived to formulate an herbal gel from the ethanolic extract of the stem bark of B. variegata Linn. and to evaluate its physicochemical parameters and microbiological assay. Materials and Methods: Formulation of 1% and 2% Gel for Antimicrobial Assay. The microbial evaluation was carried out using cup and plate method for all the formulations of gels. The Antibacterial Assay was carried with the Gram negative bacteria Escherichia coli, Vibrio parahaemolyticus , Klebsiella pneumonia, Pseudomonas aeruginosa and Gram positive bacteria such as Staphylococcus aureus and Bacillus subtilis compared with the standard ciprofloxacin. Antifungal Assay was performed against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus, and Candida albicans compared with the standard Clotrimazole. Results: The studies had revealed that the developed herbal formulations of 1% and 2% exhibited good minimum inhibitory concentration. In the antibacterial studies, a comparison made with the standard ciprofloxacin (24.5 mm), 2% ethanolic extract of the herbal gel formulation had shown the maximum effect for Bacillus subtilis (22.7 mm). In the antifungal studies, a comparison made with the standard clotrimazole (28.9 mm), 2% ethanolic extract of the herbal gel formulation had shown the maximum effect for Candida albicans (23.1 mm). Conclusion: Herbal formulations have growing demand in the world market. A very good attempt was made to establish the herbal gel containing B. variegata ethanolic extract. The studies had revealed that the developed herbal formulations of 1% and 2% exhibited good minimum inhibitory concentration. The phytoconstituents present in the bark might be responsible for the antimicrobial activity.

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    Author(s) Name:

    Malarkodi Velraj*, Dhulipalla Sowmya, D. Sindhukavi

    Affiliation(s) Name:

    Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, VISTAS, Chennai, Tamil Nadu, India

    *Corresponding author: Malarkodi Velraj, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Vels University, Chennai - 600 117, Tamil Nadu, India.

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    Author:

    Malarkodi Velraj*, Dhulipalla Sowmya, D. Sindhukavi

    Title:Formulation and evaluation of herbal gel from the ethanolic extract of the stem bark of Bauhinia variegata Linn. for antimicrobial activity
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2836-2840)
  • Experimental Methods Keywords

    Methodology:Antifungal activity, Antimicrobial activity
    Research Materials:Bauhinia variegata, Herbal gel

Keywords

Antifungal activity Antimicrobial activity Bauhinia variegata Herbal gel

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