Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004370
Title: A comparative study of pregabalin and gabapentin combinations in type 2 diabetic neuropathy patients
Category: Pharmacology
Section: Research Article
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    Introduction: Diabetes is a metabolic disorder; most of the patients are affected with nerve pain called neuropathic pain, which is acomplication that arises from diabetes called diabetic neuropathy. Diabetic Neuropathy Patients (DNP) results if the diabetic patient has high blood sugar levels for a long period. These high sugar level can damage the vessels that supplies blood to the nerve. Aim and Objective: To evaluatethe effectiveness of drug in Diabetic Neuropathic Patients (DNP). Materials and Methods: The study was carried out at general medicine department as a prospective study for 6 months using data entry form and pain rating scale form. Results: In this study,150patients with diabetic neuropathic pain were included and out of this 75 patients were given with Pregabalin + Alpha lipoic acid and remaining 75 were given with Gabapentin + Methylcobalamine therapy and the patients were selected based on the inclusion and exclusion criteria and the statistical analysis was done by Microsoft excel. Conclusion: From the present study we concluded that monotherapy with Pregabalin+Alphalipoic acid or Gabapentin+ Methylcobalamine produces clinically meaningful pain relief in patients with painful diabetic neuropathy and pain reduction was superior with Gabapentin+ Methylcobalamine compared to Pregabalin+Alphalipoic acid.

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    Author(s) Name:

    A. Vidhya, Muddala Vara Prasanna Rao*, P. Geetha

    Affiliation(s) Name:

    Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Muddala Vara Prasanna Rao, Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai - 600 117, Tamil Nadu, India

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    Author:

    A. Vidhya, Muddala Vara Prasanna Rao*, P. Geetha

    Title:A comparative study of pregabalin and gabapentin combinations in type 2 diabetic neuropathy patients
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2845-2849)
  • Experimental Methods Keywords

    Methodology:Anticonvulsants, Diabetes,A comparative study
    Research Materials:pregabalin and gabapentin

Keywords

Anticonvulsants Diabetes Gabapentin Neuropathic pain Pregabalin

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