Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004373
Title: In vitro anti-inflammatory activity of ethanolic bark extract of Guettarda speciosa (L.) by human red blood cell membrane stabilization
Category: Pharmacology
Section: Research Article
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    Introduction: The anti-inflammatory effect of medicinal plants is aimed to be evaluated as inflammation is the clinical condition associated in many disease states. Medicinal plants are widely distributed all over the different regions of India. Aim: Thus, the present study was aimed to carry out anti-inflammatory activity of bark ethanolic extracts of Guettarda speciosa which is used in ancient traditional medicine. Materials and Methods: The suppression of hypotonicity-induced human red blood cell membrane lysis was got as an estimation of the anti-inflammatory activity. Results: The percentage of membrane stabilization for methanolic extracts and diclofenac sodium was conducted at different concentrations (50–2000 μg/ml). Discussion: Hence, it can be suggested from the present study that possible mechanisms in anti-inflammatory activity were suppressing prostaglandin synthesis. Conclusion: In the future, studies are needed to evaluate in vivo anti-inflammatory activities of G. speciosa.

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    Author(s) Name:

    R. Gandhimathi 1 *, A. Saravanakumar2

    Affiliation(s) Name:

    1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2 Department of Pharmacology, Faculty of Pharmacy, Bharath Institute of Science and Technology, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gandhimathi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

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    Author:

    R. Gandhimathi 1 *, A. Saravanakumar2

    Title:In vitro anti-inflammatory activity of ethanolic bark extract of Guettarda speciosa (L.) by human red blood cell membrane stabilization
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2859-2861)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory activity, Human red blood cell membrane
    Research Materials: Diclofenac sodium, Guettarda speciosa

Keywords

Anti-inflammatory activity Diclofenac sodium Guettarda speciosa Human red blood cell membrane

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