Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004376
Title: Tyrosine kinase titration for scabies and bacterial and viral infection of human’s skin
Category: Pharmacology
Section: Research Article
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    Background: Protein tyrosine kinase (PTK) is a key regulator for cellular proliferation and differentiation, growth, and death. PTK is a potent regulator for adaptive immune response. Thus, it could be an interesting antigen for serological to determine scabies and other bacterial infections that are diagnosed presumably on subclinical symptoms. Objectives: The objectives of the study were to compare the measurement of secretory PTK in the serum of scabies-infected group, bacteria-infected group, and virus-infected groups. Materials and Methods: PTK levels were tested in the sera of 50 patients with scabies infection and 14 patients with bacterial infection and 11 patients with viral infection using human enzyme-linked immunosorbent assay (ELISA). The control of this study included healthy individuals with no history of infections. Results: PTK levels in the sera of scabies-infected group were significantly higher compared to the healthy group (1.57 ± 0.34 vs. 0.99 ± 0.12, P < 0.05). PTK levels of virus-infected patients were found not significantly higher compared to the healthy group (1.61 ± 0.32 vs. 0.99 ± 0.12, P > 0.05). High levels of PTK detected in the sera of bacteria-infected group compared to the control but statistically the difference non-significant (1.5 ± 0.14 vs. 0.99 ± 0.12, P > 0.05). Conclusion: ELISA analysis showed that PTK levels were higher in the sera of scabies patients compared to the other infected patients. Titration of PTK levels using ELISA in the sera of patients with scabies, bacterial, and viral infections could provide sensitive and specific diagnostic approach for early detection.

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    Author(s) Name:

    Azhar Jabbar Khalaf Al-Subaihawi 1 , Zinah Shakir Shallal 2 *, May Naji Al-Khanaq3 , Hadil Al-Hadi 4

    Affiliation(s) Name:

    1 Department of Medicine, College of Medicine, Wasit University, Kut, Iraq,

    2 Department of Pathological Analysis, College of Science, Wasit University, Kut, Iraq,

    3 Department of Biology, Wasit University, Kut, Iraq,

    4 School of Biomedical Sciences, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK

    *Corresponding author: Zinah Shakir Shallal, Department of Pathological Analysis, College of Science, Wasit University, Kut, Iraq.

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    Author:

    Azhar Jabbar Khalaf Al-Subaihawi 1 , Zinah Shakir Shallal 2 *, May Naji Al-Khanaq3 , Hadil Al-Hadi 4

    Title:Tyrosine kinase titration for scabies and bacterial and viral infection of human’s skin
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2880-2886)
  • Experimental Methods Keywords

    Methodology:ELISA, PTK, Scabies
    Research Materials: 50 patients

Keywords

Bacterial and viral infections ELISA PTK Scabies

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