Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004378
Title: Estimation of antibacterial activity of zinc oxide, titanium dioxide, and silver nanoparticles against multidrug-resistant bacteria isolated from clinical cases in Amara City, Iraq
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Background: Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are responsible for health-care-associated infections and hospital outbreaks, with multidrug resistance to antimicrobial agents such as aminoglycosides, carbapenems, cephalosporins, fluoroquinolones, and polymyxins. It is found that the frequent use of antibiotics has led to the emergence of nearly all antibiotic super bacteria which carry the super-resistance gene called NDM. Materials and Methods: Three species P. aeruginosa, A. baumannii, and Serratia marcescens isolated from clinical cases, their diagnosis and antibiotic susceptibility testing were achieved using Vitek2 systems depending on Gram-negative diagnosis and sensitivity cards. Results: The results revealed that P. aeruginosa and A. baumannii were resistant to antibiotics (ticarcillin, piperacillin, piperacillin/tazobactam, ceftazidime, aztreonam, imipenem, meropenem, gentamicin, tobramycin, ciprofloxacin, minocycline, and trimethoprim/sulfamethoxazole) used in this study, oppositely, S. marcescens was sensitive. The results also showed that minimum inhibitory concentration (MIC) of nanoparticles (NPs) is varying according to the type of NPs, the dimension, and bacterial species; the MIC for zinc oxide (Zn O) NP sizes (20, 30, 50, and ~ 150 nm) was determined between 625 and 2500 µg/ml, titanium dioxide (TiO2 ) NP sizes (10, 50, and 100 nm) were 3125–50,000 µg/ml, and silver NPs (AgNPs) (90 nm) were 2500 µg/ml for all isolates. In addition, our results reported that S. marcescens isolate was resistant to TiO2 (10 nm) NPs. Conclusion: Zn O NPs found to have best activity against bacterial growth compared to AgNPs and TiO2 NPs, suggesting the use of these NPs in special preparation to treat such multidrug-resistant bacteria.

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    Author(s) Name:

    Payman A. Kareem1 *, Essra G. H. Alsammak2 , Younus J. Abdullah3 , Qasim M. Bdaiwi 4

    Affiliation(s) Name:

    1 Department of Food Technology, College of Agriculture, Salahaddin University, Erbil, Iraq,

    2 Department of Biology, College of Sciences, Mosul University, Iraq,

    3 Department of Medical Labs, Amara Technical Institute, Amara City, Iraq,

    4 Al-Seder Teaching Hospital, Amara City, Iraq

    *Corresponding author: Payman A. Kareem, Department of Food Technology, College of Agriculture, Salahaddin University, Erbil, Iraq.

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    Author:

    Payman A. Kareem1 *, Essra G. H. Alsammak2 , Younus J. Abdullah3 , Qasim M. Bdaiwi 4

    Title:Estimation of antibacterial activity of zinc oxide, titanium dioxide, and silver nanoparticles against multidrug-resistant bacteria isolated from clinical cases in Amara City, Iraq
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2887-2890)
  • Experimental Methods Keywords

    Methodology:Antimicrobials agents, Minimum inhibitory concentration, Multidrug-resistant bacteria
    Research Materials:zinc oxide, titanium dioxide, and silver nanoparticles

Keywords

Antimicrobials agents Minimum inhibitory concentration Multidrug-resistant bacteria Nanoparticles

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