Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004379
Title: Antibacterial activity of date molasses against Enterobacter aerogenes isolated from burns infections in Karbala Province
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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  • Abstract

    Background: Enterobacter aerogenes is a Gram-negative bacteria belong to Enterobacteriaceae family, widely spread in nature, and it is a part of the normal flora of the intestinal tract. Recently, there have been many reports of increased nosocomial infection with these bacteria, especially in the intensive care unit. E. aerogenes opportunistic bacteria mostly causing nosocomial diseases, such as bacteremia, particularly in elderly or debilitated patients, respiratory tract infections, and urinary tract infections, particularly in catheterized patients. Materials and Methods: The current study determined the antibacterial activity of date molasses against E. aerogenes bacteria which cause burn inflammation of patients who visited or attended Al-Hussein Educational Hospital in Karbala Province. Results: The correlation between molasses and antibiotics was evaluated using fractional inhibitory concentration, and the combination results revealed that the antibacterial activity of molasses could be improved by using with antibiotics. The minimum inhibitory concentration (MIC) of molasses reached to 35 mg/ml, but the MIC of molasses in combination with ciprofloxacin and ampicillin reached to 15 and 25 mg/ml, respectively. The ability of E. aerogenes bacteria to produce hemolysin toxin, protease enzyme, and biofilm production came to be reduced when treated with MIC of date molasses. The enhanced antibacterial activity of molasses against E. aerogenes bacteria when combined with antibiotic opens the way of the other studies to show mechanical work of this combination. Conclusion: The main conclusion of this study is the enhanced antibacterial activity of molasses against E. aerogenes bacteria when combined with antibiotic, and this opens the way of the other studies to show mechanical work of this combination.

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  • About the authors and Affiliations

    Author(s) Name:

    R. A. Al-Qarraawi 1 , B. A. A. Jwad2 , S. Jaber1 , Wafaa S. Al-Wazni 1 *

    Affiliation(s) Name:

    1 Department of Biology, College of Science, University of Kerbala, Iraq,

    2 Department of Health Community, Technical Institute of Kerbala, University of Al-Furat Al-Awsat, Iraq

    *Corresponding author: Wafaa S. Al-Wazni, Department of Biology, College of Science, University of Kerbala, Iraq.

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    Author:

    R. A. Al-Qarraawi 1 , B. A. A. Jwad2 , S. Jaber1 , Wafaa S. Al-Wazni 1 *
    Title:Antibacterial activity of date molasses against Enterobacter aerogenes isolated from burns infections in Karbala Province
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2891-2895)

  • Experimental Methods Keywords

    Methodology:Antibacterial activity
    Research Materials:Date molasses

Keywords

Enterobacter aerogenes Minimum inhibitory concentration Molasses

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