Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004380
Title: The relationship between fasting serum glucagon and insulin resistance in obese and non-obese individuals
Category: Pharmacology
Section: Research Article
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    Background: Obesity is a condition manifested by an abnormal distribution of adipose or fatty tissue or excessive accumulation of fat in the body that may lead to many serious health problems such as type 2 diabetes mellitus, cardiac disease, cancers, joint problems, and respiratory and neurological problems. Methodology: One hundred people were included in this study: Classified according to their body mass index (BMI), 50 obese patients and 50 non-obese individuals. Exclusion Criteria: History of diabetes mellitus, finding of high blood glucose on biochemical examination, history of taking drugs that cause obesity or an increase in body weight, and patients with diseases of high growth hormone and pregnant women were excluded from the study. Investigations including: Fasting blood sugar, fasting serum glucagon, and fasting serum insulin were used. Insulin resistance (IR) was measured using homeostasis model of assessment IR module. Results: The mean age for the study group was 34.00 ± 9.43 years old while that of the control group was 34.50± 7.40 years old. The mean BMI for cases was 39.23 ± 6.71 kg/m² and 23.08 ± 1.19 kg/m² for the control individuals. There is association between IR and obesity as it well known and a non-significant relationship between fasting serum glucagon and obesity/IR (P > 0.05). Conclusions: Obesity is associated with IR without a high level of fasting serum glucagon.

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    Author(s) Name:

    Wathiq Essam Hameed1 , Ahmed Abdulzahra Jeyad Almurshidy1 *, Maher Jawad Kadhum2 , Doaa Mahdi Omran1

    Affiliation(s) Name:

    1 Ministry of Health of Iraq-Babil Health Directorate, Alsadik General Teaching Hospital, Iraq,

    2 Department of Public Health, Ministry of Health of Iraq-Babil Health Directorate, Iraq

    *Corresponding author: Ahmed Abdulzahra Jeyad Almurshidy, Ministry of Health, Babil Health Directorate, Iraq.

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    Author:

    Wathiq Essam Hameed1 , Ahmed Abdulzahra Jeyad Almurshidy1 *, Maher Jawad Kadhum2 , Doaa Mahdi Omran1

    Title:The relationship between fasting serum glucagon and insulin resistance in obese and non-obese individuals
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2896-2898)
  • Experimental Methods Keywords

    Methodology:diabetes mellitus, biochemical examination
    Research Materials:obese and non-obese individuals

Keywords

Glucagon Insulin resistance Obesity

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