Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004381
Title: Plasma fibrinogen as biomarker in asthmatic patients in Hila city
Category: Pharmacology
Section: Research Article
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    Background: Asthma is a chronic inflammatory process characterized by airway obstruction with hyper responsiveness to variable stimuli which reversible by drugs or by itself. A more new evidences, coagulation activation has been established in the bronchial tree of asthmatic patients. Objectives: The objective of the study was to evaluate the role of plasma fibrinogen as inflammatory biomarker in asthmatic patients. Patients and Methods: A case–control study was carried out in this study which includes 90 individuals. These subjects were divided into two groups: The first group includes 50 asthmatic patients and the second group includes 40 apparently healthy individuals. Student’s t-test was used to determine the difference in means between control and asthma groups for numerical variables using SPSS version 20.0 software. Results: The current study shows a significant changes between patients and control group parameters (forced expiratory volume in 1 s [FEV1], FEV1/forced vital capacity [FVC], fibrinogen level, and asthma control test [ACT]). Furthermore, the study reveals a significant negative correlation between plasma fibrinogen level and FEV1/FVC in patients group. The study reveals a significant negative correlation between plasma fibrinogen level and FEV1 in patients group. Furthermore, the study reveals a significant negative relationship between plasma fibrinogen level and ACT in patients group. Conclusions: The results of this study indicated increased plasma fibrinogen concentration in asthma compared to control group. This increasing correlates positively with severity of asthma and thus can be considered as biomarker in predicting status.

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    Author(s) Name:

    Ameera Jasim AL-Aaraji 1 , Monqith Abdulmohsin Aljanabi 2 , Ahmed Abdulzahra Jeyad Almurshidy2 *, Noor Moqdad Mohammed2 , Ayaat Mohammed Khaleel 2 , Mays Abbas Mohammed2

    Affiliation(s) Name:

    1 Department of Basic Science, College of Nursing, University of Babylon, Iraq,

    2 Alsadik General Teaching Hospital, Babil Health Directorate, Ministry of Health of Iraq, Iraq

    *Corresponding author: Ahmed Abdulzahra Jeyad Almurshidy, Ministry of Health of Iraq, Babil Health Directorate, Iraq

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    Author:

    Ameera Jasim AL-Aaraji 1 , Monqith Abdulmohsin Aljanabi 2 , Ahmed Abdulzahra Jeyad Almurshidy2 *, Noor Moqdad Mohammed2 , Ayaat Mohammed Khaleel 2 , Mays Abbas Mohammed2

    Title:Plasma fibrinogen as biomarker in asthmatic patients in Hila city
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2899-2903)
  • Experimental Methods Keywords

    Methodology: A case–control study ,Asthma control test
    Research Materials:asthmatic patients

Keywords

Asthma control test Asthma Fibrinogen

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