Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004382
Title: Type III secretion systems among clinical Pseudomonas aeruginosa
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Background: Pseudomonas aeruginosa is important player among many of the top ten diseases. Its important causative agent among pulmonary infections, burn and wound infections and urinary tract infections may be due to their withstanding or adaptability to survive among different habitats. Many virulence factors are responsible for this array of infections and the important one is Type III secretion systems (T3SSs). They are virulence determinant among P. aeruginosa that can orientate the infection style whether it is toxigenesis or invasiveness. Materials and Methods: Investigation of T3SS can be achieved by PCR and sequencing. Results: The results revealed that T3SS effector proteins are responsible for immune counteraction or voidance (especially interfering with phagocytosis and immaturation of interleukin IL-1B), impairment of many cellular processes, cell shape deformities, and may cause losing of cell integrity in respiratory and wound infections. Conclusion: T3SS plays a key role in pathogenesis and immune counteracting in some pseudomonal infection.

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    Author(s) Name:

    Hussein O. M. Al-Dahmoshi 1 *, Noor S. K. Al-Khafaji 1, Layth A. K. Al-Jebouri 2, Zeena H. O. Alwan1, Mohammed H. Al-Allak1, Ali Saleem Abdulridha Aridhee3

    Affiliation(s) Name:

    1 Department of Biology, College of Science, University of Babylon, Hillah, Iraq,

    2 Minstry of Education, Babylon Education Directorate, Hillah, Iraq,

    3 Department of Pharmacy, Imam Hassan College for Medical Science, Iraq

    *Corresponding author: Dr. Hussein O. M. Al-Dahmoshi, Department of Biology, College of Science, University of Babylon, Hillah, Iraq

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    Author:

    Hussein O. M. Al-Dahmoshi 1 *, Noor S. K. Al-Khafaji 1, Layth A. K. Al-Jebouri 2, Zeena H. O. Alwan1, Mohammed H. Al-Allak1, Ali Saleem Abdulridha Aridhee3

    Title:Type III secretion systems among clinical Pseudomonas aeruginosa
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2904-2908)
  • Experimental Methods Keywords

    Methodology:PCR and sequencing, Acute respiratory distress syndrome, ExoS, Type III secretion system, Wound infection
    Research Materials:Pseudomonas aeruginosa

Keywords

Acute respiratory distress syndrome ExoS Type III secretion system Wound infection

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