Journal: Drug Invention Today
Title: Investigation of SOD2 gene polymorphism in patients with chronic kidney disease in Babylon province
Category: Pharmacology
Section: Research Article
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Abstract
Background: Oxidative stress has been connected to the progressingof many diseases, like chronic kidney disease (CKD). Single-nucleotide polymorphisms (SNPs) of antioxidant enzymes may participate to some diseases that can be associated with oxidative stress. Methodology: The blood sampled from chronic kidney disease -hemodialysis patients- (thirty patients) who visit the Dialysis center in Marjan teaching hospital /Babylon /Iraq in addition to the thirty control samples. Results: PCR-SSCP results for SOD2 gene representedthe presence of two different haplotypes due to the numbers of bands in the SOD2gene including 5 and 6 bands, these haplotypes were detected between renal failure patient groups and control, sothisindicatethe association between 5 and 6bands in patients when compared with the control group. Conclusion: The current study conclude that, SSCP technique could be a good way to detect SOD2SNPs in a patient with chronic renal failure.
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About the authors and Affiliations
Author(s) Name: Dhifaf Zeki Aziz1 *, Samah Amer Hammood1 , Naser Jawad Kadhim2
Affiliation(s) Name: 1 Department of Laboratory Investigation, College of Science, University of Kufa, Iraq,
2 Department of Biology, College of Science, University of Kufa, Kufa, Iraq
*Corresponding author: Dhifaf Zeki Aziz, Department of Laboratory Investigation, College of Science, University of Kufa, Iraq.
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Author: Dhifaf Zeki Aziz1 *, Samah Amer Hammood1 , Naser Jawad Kadhim2
Title: Investigation of SOD2 gene polymorphism in patients with chronic kidney disease in Babylon province Journal: Drug Invention Today Vol(issue): 12 (October) Year: 2019 Page No: (2909-2912) -
Experimental Methods Keywords
Methodology: Antioxidant, CKD, GFR, Oxidative, PCR, SNP, SOD2 Research Materials: patients with chronic kidney disease
Keywords
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