Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004400
Title: Assessment of follistatin level in atherosclerosis patients and its relation with some anthropometric criterion as predictor survival
Category: Pharmacology
Section: Research Article
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    Background: Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenously created protein that ties activin a with high fondness and restrains its bioactivity. The essential capacity of FST is the authoritative and bioneutralization of individuals from the transforming growth factor-beta superfamily and activin a specifically. FST advances adipogenic separation of begetter cells. FST has been embroiled in aggravation and renovating, any adjustment in the level of FST, which might be a determinant of the seriousness of irritation, or tissue phenotypic change. Atherosclerosis is a dynamical procedure that rises up out of the interchange between lipid digestion, irritation, and inborn insusceptibility. Materials and Methods: The study was applied on 88 people aged 30–69 years, included 65 patients suffering from atherosclerosis disease. The FST level was assessed by enzyme-linked immunosorbent assay kit. Results: The results exhibited significant increase (P < 0.05) in FST serum level of atherosclerosis patients (11.92 ± 2.522 ng/ml) compared with healthy group (0.6703 ± 0.1012 ng/ml). Significant increase (P < 0.05) in FST serum level of female atherosclerosis patients group (10.912 ± 0.5823 ng/ml) compared with male atherosclerosis patients group (2.892 ± 0.3849 ng/ml) and also compared with male and female healthy group (0.136 ± 0.0721 ng/ml, and 0.799 ± 0.2023 ng/ml), respectively. In addition, there was significant increase (P < 0.05) in FST serum level of the healthy female group compared with the healthy male group. The results indicated that there was significant increase (P < 0.05) in FST serum level of age group of 60–69 years of atherosclerosis patients and has compared with other ages. The results showed significant increase (P > 0.05) in FST serum level in the obese weight of the atherosclerosis patients group have (8.286 ± 2.112 ng/ml) compared with (over weight and normal weight) have (4.266 ± 1.012 ng/ml and 2.221 ± 0.568 ng/ml ) respectively, and results showed significant increase (P > 0.05) in FST serum level in overweight (4.266 ± 1.012 ng/ml) compared to normal weight (2.221 ± 0.568 ng/ml). There was non-significant difference in FST serum level among healthy groups (obese weight, overweight, and normal weight) have 0.7685 ± 0.0121 ng/ml, 0.6615 ± 0.1311 ng/ml, and 0.5251 ± 0.2324 ng/ml, respectively. The results showed significant increase (P < 0.05) in FST serum level of patients group according to waist circumference (111–120 cm) compared with other waist. The results showed that significant increase (P < 0.05) in FST serum level in smokers atherosclerosis patients’ group has (13.974 ± 1.433 ng/ml) compared to nonsmokers of the atherosclerosis patients’ group, and healthy group nonsmokers have 5.949 ± 2.101 ng/ml and 0.6703 ± 0.1012 ng/ml, respectively, and nonsmokers of the atherosclerosis patients’ group compared with the healthy group nonsmokers. Conclusion: FST is the new biomarker for prognostic, staging, and detection of atherosclerosis disease.

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    Author(s) Name:

    Khama’al Hussein Abod Al-Khafaji 1 *, Ali Hassan Abood2 , Hayder Abdulkadem Nigiesh Al-Zamely3

    Affiliation(s) Name:

    1 Physiology and Pharmacology Branch, Faculty of Veterinary, University of Kufa, Iraq,

    2 Department of Biology, Faculty of Sciences, University of Kufa, Iraq,

    3 Physiology and Pharmacology Branch, Faculty of Veterinary, Al-Qasim Green University, Iraq

    *Corresponding author: Khama’al Hussein Abod Al-Khafaji, Physiology and Pharmacology Branch, Faculty of Veterinary, University of Kufa, Iraq.

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    Author:

    Khama’al Hussein Abod Al-Khafaji 1 *, Ali Hassan Abood2 , Hayder Abdulkadem Nigiesh Al-Zamely3

    Title:Assessment of follistatin level in atherosclerosis patients and its relation with some anthropometric criterion as predictor survival
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (3009-3015)
  • Experimental Methods Keywords

    Methodology:FST serum level
    Research Materials: 88 people aged 30–69 years

Keywords

Age Atherosclerosis Follistatin Gender Waist circumference

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