Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004419
Title: Anti-inflammatory and antidiabetic of Channa striata powder and Nephelium lappaceum fruit peel ethanolic extracts on albino Wistar mice
Category: Pharmacology
Section: Research Article
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    Aim: Channa striata powder (CSP) and Nephelium lappaceum fruit peel extract (NLPE) were studied for anti-inflammatory and antidiabetic activities. Materials and Methods: The investigations on albino Wistar mice for anti-inflammatory action by injecting 0.2 ml of 2% w/v carrageenan sodium subcutaneously in the sub-plantar of the mice right hind paw. Meanwhile, antidiabetic activity performed on animal model diabetic by injected alloxan. Result: The results showed that CSP, NLPE, and their combinations at dose 150 mg/kg.bw proved to significantly decreased the volume of mouse foot edema (P < 0.05). Antidiabetic activity of the combination had best activity of lowering blood glucose level of 55.6%, while CSP and NLPE could decrease blood glucose level successively 27.4% and 71.2% in mice alloxan-induced diabetic. Conclusion: The combination of CSP and NLPE has anti-inflammatory effect lower than a single extract, has antidiabetic activity in alloxan induced mice but did not show synergistic effect.

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    Author(s) Name:

    Andi Suhendi 1 , Muhtadi Muhtadi 1 *, Em. Sutrisna2

    Affiliation(s) Name:

    1 Depatment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Kartasura, Surakarta, Indonesia,

    2 Department of Pharmacology, Faculty of Medicine, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Kartasura, Surakarta, Indonesia

    *Corresponding author: Muhtadi Muhtadi, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan, Kartasura, Surakarta 57102, Indonesia

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    Author:

    Andi Suhendi 1 , Muhtadi Muhtadi 1 *, Em. Sutrisna2

    Title:Anti-inflammatory and antidiabetic of Channa striata powder and Nephelium lappaceum fruit peel ethanolic extracts on albino Wistar mice
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2472-2476)
  • Experimental Methods Keywords

    Methodology:Antidiabetic activity, Anti-inflammatory activity
    Research Materials:Channa striata, Nephellium lappaceum

Keywords

Antidiabetic activity Anti-inflammatory activity Channa striata Nephellium lappaceum

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