Journal: Drug Invention Today
Title: Central nervous system adverse effects of ertapenem in diabetic foot ulcer patients
Category: Pharmacology
Section: Research Article
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Abstract
Objectives: The objective of the study was to study the effect of ertapenem on central nervous system (CNS) and to study definite, probable, and possible CNS effects associated with ertapenem use. Materials and Methods: A total of 63 patients were in ertapenem therapy. Patients were divided into three groups. Provided with case pro forma and Naranjo probability scale, definite, probable, and possible effects are evaluated. Assessment of outcome will be done statistically among Group A, Group B, and Group C which consists of people given ertapenem for 3 days, 5 days, and 7 days, respectively. Moreover, the withdrawal effects of same groups will also be recorded after withdrawal of drug using Naranjo probability scale. Patients of the age group of 30–85 years diagnosed with diabetic foot ulcer and cellulitis. Results: The total number of 63 patients on ertapenem therapy was divided into three categories and had a total of 44 male and 19 female patients. Higher number of patients involved in this study was among the age group of 60 years. In this study, outdoor workers and people in rural population were affected more and I found that patients on ertapenem therapy for a lesser number of days had possibly less ADR and those on ertapenem therapy for more than a week had a definite and serious ADR. Conclusion: This study concluded that even though ertapenem furnishes a great effect on complicated infections. It has various adverse effects such as hallucinations, delusions, seizures, confusion, altered mental status, and some allergic reactions. On the other hand, withdrawal of ertapenem will subside the acquired adverse effects. Therefore, care must be taken while administering ertapenem and awareness must be created among the patients to avoid unwanted examinations or hospitalizations regarding altered mental status.
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About the authors and Affiliations
Author(s) Name: P. Maheshwari*, S. Nirenjen, R. V. Bibibergin, Thabitha Kumari, T. S. Shanmugarajan, P. Shanmugasundaram
Affiliation(s) Name: Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India
*Corresponding author: Ms. P. Maheshwari, Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Velan Nagar, P. V. Vaithiyalingam Road, Pallavaram, Chennai - 600 117, Tamil Nadu, India
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Author: P. Maheshwari*, S. Nirenjen, R. V. Bibibergin, Thabitha Kumari, T. S. Shanmugarajan, P. Shanmugasundaram
Title: Central nervous system adverse effects of ertapenem in diabetic foot ulcer patients Journal: Drug Invention Today Vol(issue): 12 (November ) Year: 2019 Page No: (2505-2507) -
Experimental Methods Keywords
Methodology: Adverse effects of ertapenem, Central nervous system, Diabetic foot ulcer Research Materials: Ertapenem
Keywords
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