Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004463
Title: The safety, efficacy, and quality of life of methotrexate with hydroxychloroquine as a combination versus methotrexate as monotherapy in rheumatoid arthritis: A comparative single-blinded prospecti
Category: Pharmacology
Section: Research Article
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    Objective: The objective of this investigation was to study and ascertain the effect of adjunct therapy in naïve rheumatoid arthritis (RA) patients by disease active index, quality of life (QoL), and hematological changes pre- and post-treatment. Materials and Methods: A comparative prospective study was carried out where the patients were divided into two groups, namely, combination and monotherapy groups of 30 patients each. The combination group was administered 2.5 mg and tab. hydroxychloroquine 200 mg, whereas the monotherapy was administered with tab. methotrexate (MTX) 5 mg. The hematological changes and QoL were noted during the commencement of the study and after 12 weeks of treatment. Results: The drug works together and produces synergic effect, thereby increasing the disease activity index and decreasing the disease activity score. There was statistically significant difference in the values of biomarkers in the naïve patients before and after the treatment with the combination group and monotherapy group. Conclusion: The study has significantly proved that even though MTX is the preferred drug of choice in RA, the efficacy and end results are better when given in combination with the hydroxychloroquine (disease-modifying antirheumatic drugs) making it safer and more potent.

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    Author(s) Name:

    Joyita Krishnamurthi 1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    2 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,

    3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.

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    Author:

    Joyita Krishnamurthi 1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *

    Title:The safety, efficacy, and quality of life of methotrexate with hydroxychloroquine as a combination versus methotrexate as monotherapy in rheumatoid arthritis: A comparative single-blinded prospecti
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2690-2693)
  • Experimental Methods Keywords

    Methodology:A comparative single-blinded prospective study, Rheumatoid arthritis
    Research Materials:Hydroxychloroquine, Methotrexate

Keywords

Hydroxychloroquine Methotrexate Rheumatoid arthritis

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