Journal: Drug Invention Today
Title: The safety, efficacy, and quality of life of methotrexate with hydroxychloroquine as a combination versus methotrexate as monotherapy in rheumatoid arthritis: A comparative single-blinded prospecti
Category: Pharmacology
Section: Research Article
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Abstract
Objective: The objective of this investigation was to study and ascertain the effect of adjunct therapy in naïve rheumatoid arthritis (RA) patients by disease active index, quality of life (QoL), and hematological changes pre- and post-treatment. Materials and Methods: A comparative prospective study was carried out where the patients were divided into two groups, namely, combination and monotherapy groups of 30 patients each. The combination group was administered 2.5 mg and tab. hydroxychloroquine 200 mg, whereas the monotherapy was administered with tab. methotrexate (MTX) 5 mg. The hematological changes and QoL were noted during the commencement of the study and after 12 weeks of treatment. Results: The drug works together and produces synergic effect, thereby increasing the disease activity index and decreasing the disease activity score. There was statistically significant difference in the values of biomarkers in the naïve patients before and after the treatment with the combination group and monotherapy group. Conclusion: The study has significantly proved that even though MTX is the preferred drug of choice in RA, the efficacy and end results are better when given in combination with the hydroxychloroquine (disease-modifying antirheumatic drugs) making it safer and more potent.
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About the authors and Affiliations
Author(s) Name: Joyita Krishnamurthi 1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *
Affiliation(s) Name: 1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,
2 Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India,
3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
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Author: Joyita Krishnamurthi 1 , D. Praveen2 , P. Ranadheer Chowdary2 , M. Vijey Aanandhi 3 *
Title: The safety, efficacy, and quality of life of methotrexate with hydroxychloroquine as a combination versus methotrexate as monotherapy in rheumatoid arthritis: A comparative single-blinded prospecti Journal: Drug Invention Today Vol(issue): 12 (November ) Year: 2019 Page No: (2690-2693) -
Experimental Methods Keywords
Methodology: A comparative single-blinded prospective study, Rheumatoid arthritis Research Materials: Hydroxychloroquine, Methotrexate
Keywords
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