Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004471
Title: The effect of acetylsalicylic acid and its combination with methyldopa on the functional parameters of rats in asymmetric dimethylarginine-like preeclampsia
Category: Pharmacology
Section: Research Article
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    Introduction: Preeclampsia is still one of the most common causes of maternal and perinatal mortality worldwide. Violations in the hemostatic system observed in preeclampsia can be its consequence, as well as independently exacerbate existing violations, which entails the development of a more pronounced generalized vascular spasm, increased blood pressure and, as a consequence, ischemic disorders in the organs. Objective: The objective of the study was to the protective activity of a small dose of acetylsalicylic acid (ASA) and its combination with methyldopa in the correction of asymmetric dimethylarginine (ADMA)-like preeclampsia. Materials and Methods: The study was performed on 150 female Wistar rats weighing 250-300 g. Research Results: During the series of experiments, the expressed protective activity of ASA in combination with methyldopa against morphofunctional disorders in ADMA-like preeclampsia was established. Conclusion: The combination of ASA and methyldopa is a promising direction in the treatment of preeclampsia in pregnant women.

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    Author(s) Name:

    Olga V. Severinova*, Vladimir V. Gureev, Tat’yana G. Pokrovskaya, Mikhail V. Korokin, Oleg S. Gudyrev, Volodya G. Pahlevanyan, Anastasia V. Gureeva, Vladimir I. Shutov

    Affiliation(s) Name:

    Department of Pharmacology and Clinical Pharmacology, Medical Institute, Belgorod State National Research University, 85, Pobedy St., Belgorod 308015, Russia

    *Corresponding author: Olga V. Severinova, Department of Pharmacology and Clinical Pharmacology, Medical Institute, Belgorod State National Research University, 85 Pobedy St., Belgorod, 308015, Russia.

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    Author:

    Olga V. Severinova*, Vladimir V. Gureev, Tat’yana G. Pokrovskaya, Mikhail V. Korokin, Oleg S. Gudyrev, Volodya G. Pahlevanyan, Anastasia V. Gureeva, Vladimir I. Shutov

    Title:The effect of acetylsalicylic acid and its combination with methyldopa on the functional parameters of rats in asymmetric dimethylarginine-like preeclampsia
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2722-2725)
  • Experimental Methods Keywords

    Methodology:Ischemic disorders, functional parameters
    Research Materials:Acetylsalicylic acid, Methyldopa

Keywords

Acetylsalicylic acid Ischemic disorders Methyldopa

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