Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004472
Title: Protective effects of 11-amino acid darbepoetin fragment in the experimental hypertensive neuroretinopathy
Category: Pharmacology
Section: Research Article
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    Introduction: Hypertensive retinopathy is recorded in 66.3% of patients with hypertensive disease. As authors note, there is a lack of drugs for targeted, specific correction of retinal damage, occurring in arterial hypertension (AH). Objective: The objective of the study was to improve the pharmacological correction effectiveness of retinal damage with the use of 11-amino acid darbepoetin fragment PRK-002 in the experimental hypertensive neuroretinopathy. Materials and Methods: Hypertensive neuroretinopathy simulation was performed by daily injection of N-nitro-L-arginine methyl ester for 28 days and a single increase in intraocular pressure. The retinoprotective effects of the 11-amino acid darbepoetin fragment PRK-002 in comparison with carbamylated darbepoetin and sulodexide were estimated by the changes in the b/a coefficient. Measuring the retinal microcirculation level was carried out with the use of laser Doppler flowmetry. Results and Discussion: The most pronounced protective effect is demonstrated by PRK-002 in a dose of 4 µg/kg, which is expressed in reaching the target values of the b/a and the retinal microcirculation level. When pathology was corrected by carbamylated darbepoetin in a dose of 300 µg/kg, microcirculation level increased by 41.9% (P < 0.05) in comparison with the group without correction, but did not reach the target values; b/a increased by 30.9% (P < 0.05) in comparison with the group without correction and reached the target values. When pathology was corrected by sulodexide in a dose of 150 LRU/kg, the microcirculation level in retina increased by 52.5% (P < 0.05) in comparison with the group without correction, but did not reach the target values; b/a reached the target values. Conclusion: The obtained data give an experimental substantiation of the pharmacological correction possibility of retinal damage in AH by 11-amino acid darbepoetin fragment PRK-002.

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    Author(s) Name:

    Victoria O. Gubareva1 *, Anton L. Pazhinsky1 , Nina I. Zhernakova2 , Olga V. Martynova1 , Olga A. Osipova3 , Sergey S. Lugovskoy1 , Mikhail A. Martynov1 , Maria A. Zatolokina1

    Affiliation(s) Name:

    1 Department of Pharmacology and Clinical Pharmacology, Institute of Medicine, Belgorod State University, 85, Pobedy St., Belgorod 308015, Russia,

    2 Department of Family Medicine, Institute of Medicine, Belgorod State University, 85, Pobedy St., Belgorod 308015, Russia,

    3 Department of Hospital Therapy, Institute of Medicine, Belgorod State University, 85, Pobedy St., Belgorod 308015, Russia

    *Corresponding author: Victoria O. Gubareva, Department of Pharmacology and Clinical Pharmacology, Institute of Medicine, Belgorod State University, 85, Pobedy St., Belgorod 308015, Russia.

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    Author:

    Victoria O. Gubareva1 *, Anton L. Pazhinsky1 , Nina I. Zhernakova2 , Olga V. Martynova1 , Olga A. Osipova3 , Sergey S. Lugovskoy1 , Mikhail A. Martynov1 , Maria A. Zatolokina1

    Title:Protective effects of 11-amino acid darbepoetin fragment in the experimental hypertensive neuroretinopathy
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2726-2735)
  • Experimental Methods Keywords

    Methodology: Experimental hypertensive neuroretinopathy, PRK-002, Rats
    Research Materials:11-amino acid darbepoetin fragment

Keywords

11-Amino acid darbepoetin fragment Experimental hypertensive neuroretinopathy PRK-002 Rats

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