Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004506
Title: Studying of certain immunological parameters in the Province of Babylon for systemic lupus erythematosus
Category: Pharmacology
Section: Research Article
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    Background: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with a variable clinical presentation. SLE can affect all organs, and the involvement of major organs can be life threatening. Lupus can affect many parts of the body, including the joints, skin, heart, kidneys, lungs, blood vessels, and brain. The exact pathological mechanisms of SLE remain elusive, and the etiology of SLE is known to be multifactorial. Methodology: The investigation subjects consisted of 30 sick people suffering from SLE collected randomly from the Merjan Teaching Hospital (28 female and 2 male patients) as a patients group of SLE with average age (10–50 years), the investigation of control group would include 15 apparently healthy patients including (6 female and 9 male patients) with average age (20–50 years), this group complemented the group of patients. Results: Patients with SLE were divided by age into groups. The age group (11–20) was the first age group, the infection rate was 13.4%, while the second age group (21–30) the infection rate was 26.6%, the third age group (31–40) the infection rate was 46.6%, was the highest, and the fourth age group (41–50) the infection rate was 13.4%. Results of study groups distribution by sex showed that the rate of infection in females was relatively higher than males 93.3% and 6.7%, respectively. Moreover, the overall duration of SLE was 73.3% of sick people who suffer from SLE who suffering from the disease for lesser than 5 years as a total duration. About 53.4% of patients who suffer from SLE were complained from rash of different body parts. Results of antinuclear antibody test (ANA test), show (80%) of patients are positive result, while (20%) of patients have a negative result. While the results of C-reactive protein concentration measurement showed an increase in the concentration of the age groups. Immunoglobulin distribution of SLE patients revealed the highest average immunoglobulin G of sick people who suffer from SLE (1203.05 ± 5.08) mg/dl, while the lowest average immunoglobulin A (125.9 ± 4.35) was mg/dL. The average immunoglobulin M was among patients (45.6 ± 4.25) mg/dL. Conclusion: Systemic Lupus Erythematosus disease is more common among females than males, In this study patients with SLE disease have elevated levels of ANA and CRP. and we have shown the differential expression of IgG, IgM, and IgA in SLE patients.

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    Author(s) Name:

    Marwa Fadhil Alsaffar*

    Affiliation(s) Name:

    Department of Medical Laboratory Techniques, AL-Mustaqbal University College, Hillah, Iraq

    *Corresponding author: Marwa Fadhil Alsaffar, Department of Medical Laboratory Techniques, AL-Mustaqbal University College, Hillah, Iraq.

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    Author:

    Marwa Fadhil Alsaffar*

    Title:Studying of certain immunological parameters in the Province of Babylon for systemic lupus erythematosus
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2835-2839)
  • Experimental Methods Keywords

    Methodology: Antinuclear antibody test, C-reactive protein, immunological parameters
    Research Materials:30 sick people suffering from SLE

Keywords

Antinuclear antibody test C-reactive protein Immunoglobulin Systemic lupus erythematosus

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