Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004507
Title: Genetic variation of the Apo CII gene and plasma lipid levels in healthy and patients with acute coronary syndrome
Category: Pharmacology
Section: Research Article
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    Background: Genetic polymorphisms in apolipoprotein C2 (APOC2) genes maybe relationship with modification in lipid profile and susceptibility to acute coronary syndrome (ACS). The current study aims to investigate some of the causes of ACS through study APOC2 gene polymorphisms in the Babylon Center population and to investigate the relation of these polymorphisms with lipid, and APOC2 levels. Materials and Methods: In this study, participants were 120 men of age group between (40-65) years old and BMI of 20-29.9 kg/m2 . Study group (60 men) included smokers with hypertension and no other risk factors for ACS. On the other hand, control group included 60 men who were nonsmokers, no hypertensive, with no systemic diseases. The serum sample was used to measure the concentration of total cholesterol (CL), triglyceride (TG), and high-density lipoprotein (HDL) using colorimetric methods, low-density lipoprotein (LDL) was calculated using the Friedewald equation, APOC2 level by enzyme-linked immunosorbent assay method, and DNA was extracted from leukocytes in the blood samples to study APOC2 gene. Results: Revealed the relationship between levels of APOC2 concentration and the polymorphism of the APOC2 gene a significant elevated in A1A2 genotype. In addition, there was a significantly increase in CL and LDL and significantly decrease in HDL with genotype A1A1 and genotype A1A2 showed significantly increase in TG and very-LDL compared with other genotypes. Conclusion: APOC2 gene polymorphism contributed to the occurrence of the ACS, where A1A1 genotype has a higher level of total CL and LDL and this increases the incidence of atherosclerosis, increased concentration of APOC2 play a role in the occurrence of ACS by interfering with the action of lipoprotein lipase, and this may increases the level of TGs.

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    Author(s) Name:

    Rafil Sabik Hussain*, Maha F. Smaism, Moshtak A. Wtwt

    Affiliation(s) Name:

    Department of Biochemistry, College of Medicine, University of Babylon, Hillah, Iraq


    *Corresponding author: Rafil Sabik Hussain, College of Medicine, University of Babylon, Hillah, Iraq.

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    Author:

    Rafil Sabik Hussain*, Maha F. Smaism, Moshtak A. Wtwt

    Title:Genetic variation of the Apo CII gene and plasma lipid levels in healthy and patients with acute coronary syndrome
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2840-2844)
  • Experimental Methods Keywords

    Methodology: Apolipoprotein C2, Apolipoprotein C2 gene polymorphism, Lipid profile
    Research Materials:Acute coronary syndrome

Keywords

Acute coronary syndrome Apolipoprotein C2 Apolipoprotein C2 gene polymorphism Lipid profile

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