Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004508
Title: The role of luteinizing hormone receptor gene (rs2293275) polymorphism on luteinizing hormone level in women with polycystic ovarian syndrome
Category: Pharmacology
Section: Research Article
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    Background: The aim of this study was to determine the genetic relation of luteinizing hormone/choriogonadotropin receptor gene (rs2293275) polymorphism on luteinizing hormone level in women polycystic ovarian syndrome (PCOS), which affects 5–10% of all women of reproductive age. Materials and Methods: A cross-sectional study was conducted on 88 Iraqi women diagnosed with PCOS. The females were divided into two groups 43 patients (Group A) with regular secretion of LH and 45 patients (Group B) with irregular secretion of LH. All females were assessed the status of obesity by body mass index (BMI) and blood samples were taken from these two groups for hormones and gene expression analysis. Results: LH receptors genotype and allele frequency was specified G935A polymorphism in the two group, Group A genotype, contain on 51.18% were wild genotype (GG), 32.55% were heterozygous (GA), and 16.27% were homozygous genotype (AA), while Group B appeared 42.22% were GG, 37.78% were GA, and 20.0% were AA. Regarding, hormones showed significant increase in LH level in Group B compared with Group A (18.91 ± 3.07 mlU/ml and 5.47 ± 0.49 mlU/ml, respectively). The mean value of other hormone levels was different in both study groups but remained within normal range. The age, BMI, and duration of infertility did not differ between Group A and B. Conclusion: From this study, we concluded the choriogonadotropin receptor gene (rs2293275) polymorphism effected on the LH level especially the women carrying GA genotype or A allele which has high risk to develop high LH level with PCOS.

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    Author(s) Name:

    Haitham Mohammed Saad1 *, Maha Fadhal Smaism2 , Nadia Mudher Sulaiman3

    Affiliation(s) Name:

    1 Department of Medical Laboratory, Ministry of Health, Al-Anbar Health Directorate, Ramadi, Iraq,

    2 Department of Clinical Biochemistry, College of Medicine, University of Babylon, Hillah, Iraq,

    3 Department of Obstetrics and Gynecology, College of Medicine, University of Babylon, Hillah, Iraq

    *Corresponding author: Haitham Mohammed Saad, Department of Medical Laboratory, Ministry of Health, Al-Anbar Health Directorate, Ramadi, Iraq.

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    Author:

    Haitham Mohammed Saad1 *, Maha Fadhal Smaism2 , Nadia Mudher Sulaiman3

    Title:The role of luteinizing hormone receptor gene (rs2293275) polymorphism on luteinizing hormone level in women with polycystic ovarian syndrome
    Journal:Drug Invention Today
    Vol(issue):12 (November )
    Year:2019
    Page No: (2845-2849)
  • Experimental Methods Keywords

    Methodology:Luteinizing hormone, Luteinizing hormone receptor gene, Polycystic ovary syndrome
    Research Materials:43 patients

Keywords

Luteinizing hormone Luteinizing hormone receptor gene Polycystic ovary syndrome rs2293275 polymorphism

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