Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004513
Title: An in silico study on the protein network interaction induced by capsaicin against dental pathogens
Category: Pharmacology
Section: Research Article
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    Introduction: The present investigation is designed to analyze the possible protein interactions of the potent phytocompound capsaicin with the common dental pathogens together with the assessments of functional class of the proteins, virulence nature, and subcellular location using in silico tools. Materials and Methods: The study follows an in silico design, where computational tools are used to derive the preliminary data on the molecular interactions of the drug with the protein repertoire of the pathogens. The interaction was assessed by the STITCH tool followed by the evaluation of the functional class of the protein and its virulence using VICMPred and VirulentPred. PSORTb and BepiPred were used to identify the subcellular location and epitopes on the virulent protein targeted by capsaicin. Results: Several virulence factors were found to be targeted by capsaicin. Molecular chaperone was found to be the common virulence factor in most of the pathogens followed by choloylglycine hydrolase of Enterococcus faecalis, conserved hypothetical protein of Streptococcus mutans, ABC transporter ATP-binding protein and superoxide dismutase of Porphyromonas gingivalis, and pyruvate kinase of Treponema denticola and Tannerella forsythia. Conclusion: Capsaicin could be used as an antimicrobial agent, especially against dental pathogens as it was found to target some of the crucial proteins such as molecular chaperones of the dental pathogens.

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    Author(s) Name:

    A. Alagu Rathi Bharathi 1, A. S. Smiline Girija1,J.Vijayashree Priyadharsini2*

    Affiliation(s) Name:

    1 Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Vijayashree Priyadharsini, Biomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    A. Alagu Rathi Bharathi 1, A. S. Smiline Girija1,J.Vijayashree Priyadharsini2*

    Title:An in silico study on the protein network interaction induced by capsaicin against dental pathogens
    Journal:Drug Invention Today
    Vol(issue):11 (December [ Special Issue 2])
    Year:2019
    Page No: (8-14)
  • Experimental Methods Keywords

    Methodology:An in silico study
    Research Materials:Capsaicin, Chaperons

Keywords

Capsaicin Chaperons Dental pathogens In silico Transporters

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