Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004530
Title: Effect of nanoparticles incorporated into herbal substitutes against endodontic microorganisms
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Introduction: This study aims to evaluate the antimicrobial effect of nanoparticles incorporated into herbal substitutes against endodontic infections. Materials and Methods: The samples (30) were screened for antibacterial activity against Enterococcus faecalis using agar well diffusion method. The extract was mixed with ethanol and vortexed for maximum dissolution. Luria-Bertani agar plates were inoculated with test organism. The plates were evenly spread out. Then, wells were prepared in the plates with a cork borer. Each well was loaded with 50 µl. The plates were incubated for 24 h at 37°C. The development of the inhibition zone around the well was measured (diameter) and recorded. Tetracycline was used as a positive control. Results: In this in vitro study, we assessed the antimicrobial efficacy of sliver nanoparticles with Calotropis gingantea extract and tetracycline against E. faecalis. The antimicrobial activity of nanosilver particles with C. gingantea extract was moderate compared to that of conventional tetracycline. Tetracycline rapidly killed the bacteria in the Petri dish, only partial disinfection can be achieved in the surface wall of the root canal and tetracycline was relatively effective. More the concentration of the sample, more is the antibacterial effect of the sample. Conclusion: Silver nanoparticles incorporated into the extract C. gingantea against E. faecalis are less effective than tetracycline. Therefore, increasing concentration of the extract C. gingantea in nanoparticles can be assessed in the future.

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    Author(s) Name:

    Rushabh Kamdar1 , Chandana Subbarao2 , Dhanraj Ganapathy1 *

    Affiliation(s) Name:

    1 Department of  Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Conservative Dentistry and Endodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India

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    Author:

    Rushabh Kamdar1 , Chandana Subbarao2 , Dhanraj Ganapathy1 *

    Title:Effect of nanoparticles incorporated into herbal substitutes against endodontic microorganisms
    Journal:Drug Invention Today
    Vol(issue):11 (December [ Special Issue 2])
    Year:2019
    Page No: (94-97)
  • Experimental Methods Keywords

    Methodology:Antibacterial pattern
    Research Materials:Calotropis gingantea, Enterococcus faecalis, Silver nanoparticles

Keywords

Antibacterial pattern Calotropis gingantea Enterococcus faecalis Silver nanoparticles

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