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Abstract

Context: A diabetic wound in diabetes patients is involved in the peripheral and autonomic nervous systems. The temulawak extract as essential oils and curcumin can improving wound healing process. Aims: This research was aimed to observe temulawak extract in decreasing erythema level and the macrophages present in the healing of diabetic wounds in a male diabetes mellitus (DM) Wistar rat. Settings and Design: This study used true experimental laboratory research design with randomized post-test only control group design method. Subjects and Methods: DM was induced in white male Wistar rats using streptozotocin 40 mg/kg BW intraperitoneally then divided into five experimental groups. Three groups were administered by various doses of temulawak extract (15%, 20%, and 25%) and two groups were administered by saline and Vaseline solution as a control comparison. Statistical Analysis Used: One way ANOVA test can be performed to determine the influence of temulawak extract. Furthermore, the post hoc test was performed to determine the difference between the control and treatment groups, while the parametric test of linear regression was performed to know the influence of temulawak extract to the erythema level and the macrophage presences. Results: This research obtained that Group 2 (temulawak 20%) had the most significant influence of erythema level and macrophage presence. Temulawak extract had the influence to decrease erythema level (P = 0.041) and macrophage presence (P = 0.002). Conclusions: Temulawak (Curcuma xanthorrhiza Roxb.) has potential to decrease the level of erythema and the presence of macrophages during the wound healing process of diabetes in a male Wistar rat DM model.

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	JPR Solutions

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