Journal: Drug Invention Today
Title: Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate
Category: Pharmacology
Section: Research Article
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Abstract
Objective: The current work was conducted with the aim of preparing rapidly dissolving strips of dexchlorpheniramine maleate to improve pediatric patient adherence for the best pharmaceutical reaction through the first-pass hepatic metabolism bypass. Methods: The oral strip was prepared using various polymers hydroxypropyl methylcellulose (HPMC E15, HPMC K4M, and polyvinyl alcohol) using solvent casting methodology. Various types of plasticizers polyethylene glycol (PEG 400 and propylene glycol) have been used to raise the features of the strip preparation polymer. Results: From this work, formula 3, consisting of 360 mg HPMC E15 as a polymer and 1 ml PEG 400 as a plasticizer, offers acceptable formulation characteristics and rapid drug release (100%) at 10 min compared to the Polaramine®(Schering-Plough) tablets (66.18%) on the market. Conclusion: The optimum formula (F3) has been chosen to prepare rapidly dissolving strips to be useful for pediatric drug dosage by offering quicker release and better patient compliance.
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About the authors and Affiliations
Author(s) Name: Ahmed A. Albadri 1 *, Yasir Q. Almajidi 1 , Anmar A. Abdelrazzaq2
Affiliation(s) Name: 1 Department of Pharmaceutics, Baghdad College of Medical Sciences, Baghdad, Iraq,
2 Department of Pharmaceutics, College of Pharmacy, Al-Esraa University College, Baghdad, Iraq
*Corresponding author: Ahmed A. Albadri. Department of Pharmaceutics, Baghdad College of Medical Sciences, Baghdad, Iraq
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Author: Ahmed A. Albadri 1 *, Yasir Q. Almajidi 1 , Anmar A. Abdelrazzaq2
Title: Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate Journal: Drug Invention Today Vol(issue): 11 (December ) Year: 2019 Page No: (3209-3213) -
Experimental Methods Keywords
Methodology: Preparation and in vitro characterization Research Materials: dexchlorpheniramine maleate
Keywords
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