Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004607
Title: Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate
Category: Pharmacology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objective: The current work was conducted with the aim of preparing rapidly dissolving strips of dexchlorpheniramine maleate to improve pediatric patient adherence for the best pharmaceutical reaction through the first-pass hepatic metabolism bypass. Methods: The oral strip was prepared using various polymers hydroxypropyl methylcellulose (HPMC E15, HPMC K4M, and polyvinyl alcohol) using solvent casting methodology. Various types of plasticizers polyethylene glycol (PEG 400 and propylene glycol) have been used to raise the features of the strip preparation polymer. Results: From this work, formula 3, consisting of 360 mg HPMC E15 as a polymer and 1 ml PEG 400 as a plasticizer, offers acceptable formulation characteristics and rapid drug release (100%) at 10 min compared to the Polaramine®(Schering-Plough) tablets (66.18%) on the market. Conclusion: The optimum formula (F3) has been chosen to prepare rapidly dissolving strips to be useful for pediatric drug dosage by offering quicker release and better patient compliance.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Ahmed A. Albadri 1 *, Yasir Q. Almajidi 1 , Anmar A. Abdelrazzaq2

    Affiliation(s) Name:

    1 Department of Pharmaceutics, Baghdad College of Medical Sciences, Baghdad, Iraq,

    2 Department of Pharmaceutics, College of Pharmacy, Al-Esraa University College, Baghdad, Iraq

    *Corresponding author: Ahmed A. Albadri. Department of Pharmaceutics, Baghdad College of Medical Sciences, Baghdad, Iraq

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Ahmed A. Albadri 1 *, Yasir Q. Almajidi 1 , Anmar A. Abdelrazzaq2

    Title:Preparation and in vitro characterization of pediatric fast dissolving strip of dexchlorpheniramine maleate
    Journal:Drug Invention Today
    Vol(issue):11 (December )
    Year:2019
    Page No: (3209-3213)
  • Experimental Methods Keywords

    Methodology:Preparation and in vitro characterization
    Research Materials:dexchlorpheniramine maleate

Keywords

Hydroxypropyl methylcellulose E15 Pediatric Polyethylene glycol 400 Strip

Our Services

Most Downloaded List