Journal: Drug Invention Today
Title: The relaxation effect of ethanolic extract of Biwa leaves (Eriobotrya japonica) on the histamine-1 receptor in isolated guinea pigs tracheal
Category: Pharmacology
Section: Research Article
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Abstract
Background: Eriobotrya japonica or Biwa (family of Rosaceae) is one of the traditional medicines that used for bronchitis and cough. Objective: The aims of the study were to investigate the relaxation effect of the ethanolic extract of E. japonica leaves on the isolated guinea pig tracheal induced by histamine and its mechanism on phosphodiesterase-3 (PDE-3), nitric oxide, and prostaglandin. Materials and Methods: The study of the relaxation effect of the ethanolic extract (1–8 mg/mL) on the contraction of histamine 4.6 × 10−4 M was conducted in vitro using isolated guinea pig tracheal organ in the Krebs solution. Mechanistic evaluation was carried out by organ pre-incubation using theophylline, L-NAME, and acetosal. Results: The results showed that the ethanolic extract of E. japonica leaves produced a relaxation effect on histamine-induced contraction on guinea pig isolated tracheal and it was concentration-dependent manner. Relaxation percentages at the extract concentration of 8 mg/ml reached 43.24 ± 7.09%. The mechanism of the relaxation effect of the extract is mediated through PDE-3 inhibition, the prostaglandin pathway, and the nitric oxide pathway. Conclusion: The ethanolic extract of E. japonica leaves showed a relaxation effect on histamine induced-contraction mediated through PDE-3 inhibition, prostaglandin, and nitric oxide pathway.
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About the authors and Affiliations
Author(s) Name: Dadang Irfan Husori 1,2 , Marianne1,2 *, Astari Karini Lubis1 , Dwi Tami Annisa Zulfita1
Affiliation(s) Name: 1 Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia,
2 Indonesia Medicinal Plant Research Community, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia
*Corresponding author: Marianne, Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
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Author: Dadang Irfan Husori 1,2 , Marianne1,2 *, Astari Karini Lubis1 , Dwi Tami Annisa Zulfita1
Title: The relaxation effect of ethanolic extract of Biwa leaves (Eriobotrya japonica) on the histamine-1 receptor in isolated guinea pigs tracheal Journal: Drug Invention Today Vol(issue): 12 (December ) Year: 2019 Page No: (2924-2927) -
Experimental Methods Keywords
Methodology: relaxation effect Research Materials: Eriobotrya japonica
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