Journal: Drug Invention Today

Article Id: JPRS-P'Col-00004805
Title: Beneficial role of aspirin as antioxidant agents
Category: Pharmacology
Section: Research Article
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    Background: Aspirin which is an acetylsalicylic acid (ASA) is used widely for the secondary prevention of cardiac diseases such as ischemic cerebrovascular events. This beneficial role is due to the antiplatelet aggregation action in the body that prevents arterial platelet thrombi formation. Furthermore, it has been assumed that ASA is able to prevent cerebrovascular accidents by its action as neuroprotective effect through a direct action on brain tissue. It has been also postulated that aspirin and mainly its metabolite SA prevent the oxidative stress. Materials and Methods: A clinical trial study, in which 100 individuals have been selected from Al Sader Teaching Hospital in Al Najaf Al Ashraf, Iraq, divided into two groups: Group A contains 60 individuals used aspirin and Group B contains 40 individuals not use aspirin, ferritin (FER) concentration, malondialdehyde (MDA), reduced glutathione (GSH), and superoxide dismutase (SOD) levels in serum, which were estimated as antioxidant parameters to show the oxidation state in both groups, then Group A was subdivided into subgroups to show the effect of ages and duration of aspirin use on the state of oxidation. Results: It was observed that there is a significant increase in MDA with a significant decrease in FER, GSH, and SOD in Group B when compared with Group A and significant increase in MDA with a significant decrease in FER, GSH, and SOD in subgroups toward advanced age and low duration for use aspirin. Conclusion: Aspirin has antioxidant action and its usage to reduce oxidative stress, especially to aged individuals, is very important to prevent oxidative damage to the cardiovascular system.

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    Author(s) Name:

    Laith A. Younus*

    Affiliation(s) Name:

    Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Jabir Ibn Hayyan Medical University, Al Najaf Al Ashraf, Iraq

    *Corresponding author: Laith A. Younus, Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Jabir Ibn Hayyan Medical University, Al Najaf Al Ashraf, Iraq.

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    Author:

    Laith A. Younus*

    Title:Beneficial role of aspirin as antioxidant agents
    Journal:Drug Invention Today
    Vol(issue):13 (February )
    Year:2020
    Page No: (265-268)
  • Experimental Methods Keywords

    Methodology:Cardiovascular, Oxidative stress, Beneficial role
    Research Materials:Aspirin

Keywords

Aspirin Cardiovascular Oxidative stress Salicylic acid

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