Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000493
Title: Phytochemical investigation and effect of various extracts of Argemonemexicana (Papaveraceae) leaves onclonidine and haloperidol-induced catalepsy in mice
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    Preliminary phytochemical investigation of petroleum ether, chloroform, acetone, methanol and aqueous extract of leaves of Argemone mexicana Linn. shows the presence of sterols, flavanoids, tannins, glycosides and alkaloids. These extracts were evaluated for anticataleptic activity. Leaves of A. mexicana were traditionally used as antiasthamatic. For induction of catalapsy, clonidine and haloperidol were used. All extracts at 50 mg/kg, i.p. showed significant activity. Amongst all the extracts and standard drug pheniramine maleate at 10 mg/ kg, i.p. aqueous extract of leaves significantly inhibit clonidine-induced catalepsy but do not inhibit haloperidol induced-catalepsy. It may be concluded that antihistaminic activity may be due to polar constituents of Argemone mexicana.

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    Author(s) Name:

    R.D. Bhalke*Y.P. Mandole, N.B.Mali

    Affiliation(s) Name:

    *Department of Pharmacognosy,Sanjivani College of Pharmaceutical Education and research, Kopergaon,M.S. India.

    For correspondence:Miss. Rasika D. Bhalke,Head, Department of Pharmacognosy, Sanjivani College of Pharmaceutical Education and research, Kopergaon,Pin- 423603, Maharashtra, India.


    Received on:12-12-2008; Accepted on :08-02-2009

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    Author:

    R.D. Bhalke*Y.P. Mandole, N.B.Mali

    Title:Phytochemical investigation and effect of various extracts of Argemonemexicana (Papaveraceae) leaves onclonidine and haloperidol-induced catalepsy in mice
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (April)
    Year:2009
    Page No: (765-767)
  • Experimental Methods Keywords

    Methodology:cataleptic activity, antiasthamatic
    Research Materials:Argemone mexicana

Keywords

Argemone mexicana cataleptic activity antiasthamatic clonidine haloperidol.

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