Journal: Drug Invention Today

Article Id: JPRS-DFP-00005015
Title: Phytochemical screening and in vitro anti-dandruff activities of bark extracts of neem (Azadirachta indica)
Category: Drugs from Plants
Section: Research Article
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    Introduction: Malassezia globosa has been linked to several skin diseases such as seborrheic dermatitis, folliculitis, and pityriasis vesicular and atopic dermatitis. Although several synthetic anti-dandruff drugs used for the treatment of M. globosa- related dandruff, most of them are not effective due to the development of antifungal resistance. Azadirachta indica is widely used medicinal plant used in traditional by many people in among the globe for curing the both infectious and non-infectious diseases. Objective: The objective of the present study was to conduct the phytochemical screening and evaluation of in vitro anti-dandruff activities of bark organic extracts of neem (A. indica) using different solvents; diethyl ether, chloroform, ethyl acetate, ethanol, and water. Materials and Methods: Young stem (bark neem) was extracted with solvents of varying polarity, namely, diethyl ether, chloroform, acetone, and ethanol. The in vitro anti-dandruff activity of the extracts was evaluated against multidrug-resistant species of M. globosa and Malassezia restricta. Results: The ethanolic bark extract of A. indica was shown 5.25 g/100 g of percentage yield following 3.84 g, 1.13 g, 2.37 g, and 3.00 g of extracts of aqueous water, diethyl ether, chloroform, and ethyl acetate, respectively, which were obtained. As a result, the highest zone of inhibition was obtained in ethanol solvent 14 mm (8.57 ± 3.4) at 100 μg/ml. Besides, 12 mm (7.57 ± 2.6), 11 mm (7.28 ± 2.9), 10 mm (7.00 ± 2.5) and 9 mm (5.85 ± 2.0) for aqueous, ethyl acetate, chloroform and diethyl ether, respectively. The phytochemical screening of ethanolic bark extract of A. indica revealed the presence of secondary metabolites such as alkaloids (azadirachtin), flavonoids (sodium nimbinate), tannins (salannin) and phenolic compounds, terpenoids (nimbin, nimbolinin and nimbidin) and steroids (nimbidol) responsible for anti-dandruff activity against two malassezia species such as (M. globosa and M. restricta). Conclusion: The present results indicate that infected persons can be used neem as antifungal agents. The polar (ethanol and aqueous water) extracts have a more secondary metabolites and potential source of antifungal agents.

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    Author(s) Name:

    Gebrehiwot Gebremedhin1 , Teklemichael Tesfay1 *, K. Krishna Chaithanya2 , K. Kamalakararao3

    Affiliation(s) Name:

    1 Department of Biology, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,

    2 Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia,

    3 Departments of Biochemistry, Adikavi Nannaya University, Rajahmundry, Andhra Pradesh, India

    *Corresponding author: Teklemichael Tesfay, Department of Biology, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia.

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    Author:

    Gebrehiwot Gebremedhin1 , Teklemichael Tesfay1 *, K. Krishna Chaithanya2 , K. Kamalakararao3

    Title:Phytochemical screening and in vitro anti-dandruff activities of bark extracts of neem (Azadirachta indica)
    Journal:Drug Invention Today
    Vol(issue):13 (May)
    Year:2020
    Page No: (707-713)
  • Experimental Methods Keywords

    Methodology:Phytochemical screening , in vitro anti-dandruff activities
    Research Materials:neem (Azadirachta indica)

Keywords

Dandruff Ketoconazole Malassezia species Phytochemicals

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