Journal: Drug Invention Today

Article Id: JPRS-P'ceu-00005079
Title: Design, formulation, and evaluation of reservoir-type transdermal delivery of an antihypertensive drug
Category: Pharmaceutics
Section: Research Article
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    Aim: The purpose of this study was to develop a reservoir-type transdermal delivery system for losartan potassium. The developed patch consisted of four layers from bottom to top, namely, a fabric with adhesive layer, a rate-controlling membrane, a reservoir, and a backing. Materials and Methods: In the present study, reservoir device was prepared using rate-controlling membrane ethylene vinyl acetate, two-layer backing membrane of 4% w/w polyvinyl acetate and 12% w/w ethylene vinyl acetate and gel system of Carbopol 934P. Reservoir-type transdermal delivery system was further analyzed for their appearance, pH, viscosity, and drug content of gel, in vitro diffusion studies. Optimized formulation was further subjected to stability studies. Results and Conclusion: In vitro drug diffusion studies exhibited concentration-dependent controlled release of losartan potassium for 8 h. Optimized formulation (X1) was subjected to accelerated stability studies which revealed the stability of the formulation. Thus, it was concluded that transdermal patches of losartan potassium can be developed for treating hypertension.

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    Author(s) Name:

    F. S. Dasankoppa1 *, M. Channavanavar1 , H. N. Sholapur2 , V. G. Jamakandi1

    Affiliation(s) Name:

    1 Department of Pharmaceutics, KLE College of Pharmacy, (Affiliated to KLE Academy of Higher Education and Research), Belagavi, Karnataka, India,

    2 Department of Pharmacognosy, KLE College of Pharmacy, (Affiliated to KLE Academy of Higher Education and Research), Belagavi, Karnataka, India

    *Corresponding author: F. S. Dasankoppa, Department of Pharmaceutics, KLE College of Pharmacy, (Affiliated to KLE Academy of Higher Education and Research), Belagavi, Karnataka, India.

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    Author:

    F. S. Dasankoppa1 *, M. Channavanavar1 , H. N. Sholapur2 , V. G. Jamakandi1

    Title:Design, formulation, and evaluation of reservoir-type transdermal delivery of an antihypertensive drug
    Journal:Drug Invention Today
    Vol(issue):14 (June )
    Year:2020
    Page No: (848-853)
  • Experimental Methods Keywords

    Methodology:Design, formulation, and evaluation , Permeation Rate controlled, Reservoir type transdermal system
    Research Materials:Losartan potassium

Keywords

Ethylene vinyl acetate Losartan potassium Permeation Rate controlled Reservoir type transdermal system

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