Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000528
Title: Evaluation of Anticonvulsant activity of methanolic extract of Artocarpus heterophyllus lam. (Moraceae) in mice.
Category: Pharmacology
Section: Research Article
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  • Abstract

    The Artocarpus heterophyllus lam. has been documented as a potent agent for the treatment of convulsions and neurodegenerative disorders. Thus the methnolic extracts of Artocarpus heterophyllus lam. (Moraceae) was investigated for its anti-convulsant property. The methnolic extract of heart wood of Artocarpus heterophyllus (MEAH) at graded doses (250,500mg/kg, po) in mice was assessed using pentylenetetrazole (PTZ), strychnine and maximal electroshock seizure (MES) test. The extract significantly and dose dependently delayed the onset of clonic convulsion induced by pentylenetetrazole, strychnine, and duration of extensor phase in maximal electroshock seizure. MEAH has complex action on central nervous system although it exhibited anticonvulsant activity against PTZ, strychnine and MES induced.

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    Author(s) Name:

    A.P.Jain*, M.V.Tote, N.B.Mahire, V.R.Undale, A.V.Bhosale

    Affiliation(s) Name:

    *Department of Pharmacology. P.D.E.A’S S. G. R. S. College of Pharmacy, Saswad, Pune. (MS), India 412301.


    Received on: 12-01-2009; Accepted on: 07-03-2009

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    Author:

    A.P.Jain*, M.V.Tote, N.B.Mahire, V.R.Undale, A.V.Bhosale

    Title:Evaluation of Anticonvulsant activity of methanolic extract of Artocarpus heterophyllus lam. (Moraceae) in mice.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (June)
    Year:2009
    Page No: (1004-1007)
  • Experimental Methods Keywords

    Methodology:Anticonvulsant activity
    Research Materials:Artocarpus heterophyllus

Keywords

Anticonvulsant Artocarpus heterophyllus MES PTZ Strychnine.

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