Journal: Drug Invention Today

Article Id: JPRS-pp-00005314
Title: A case report on mycophenolate mofetil-induced acute hepatitis in patient diagnosed with autoimmune hemolytic anemia and chronic calcific pancreatitis
Category: Pharmacy Practice
Section: Case Studies
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    Autoimmune hemolytic anemia (AIHA) is a rare disease condition caused by the formation of the autoantibodies against patient’s own erythrocytes. Clinical signs to identify the disease condition include generalized weakness, yellowish discoloration of skin, and tachycardia, and it is diagnosed by clinical laboratory evidence on direct antiglobulin test, indirect bilirubinemia, and serum lactate dehydrogenase levels. AIHA is treated with corticosteroids as first-line therapy, splenectomy, or immunosuppressants as second-line therapy and azathioprine mycophenolate (Mycophenolate mofetil [MMF]) as third- line therapy. MMF is a pro-drug converted to mycophenolic acid in the human body which restrains the proliferation of both T and B lymphocytes by selective inhibition of inosine monophosphate dehydrogenase for de novo guanine pathway for RNA and DNA synthesis. The prominent adverse drug reactions for MMF are leukopenia, fever, abdominal pain, anemia, dyspnea, and back pain. The elevation of serum hepatic transaminases due to MMF was rarely reported in the literature. There are few cases reports on MMF-induced hepatic abnormalities when it was used in organ transplantation patients. However, till date, there are no reports on MMF-induced hepatitis when it is given for AIHA. Here, we have presented a case of 36-year-old patient with MMF-induced acute hepatitis, who was previously diagnosed with AIHA and chronic calcific pancreatitis.

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    Author(s) Name:

    Landa Vikash, Hathur Basavana Gowdappa, Siddartha N. Dhurappanavr, Madhan Ramesh*

    Affiliation(s) Name:

    Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India

    *Corresponding author: Dr. Madhan Ramesh, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagara, Mysuru - 570 015, Karnataka, India.

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    Author:

    Landa Vikash, Hathur Basavana Gowdappa, Siddartha N. Dhurappanavr, Madhan Ramesh*

    Title:A case report on mycophenolate mofetil-induced acute hepatitis in patient diagnosed with autoimmune hemolytic anemia and chronic calcific pancreatitis
    Journal:Drug Invention Today
    Vol(issue):13 (February )
    Year:2020
    Page No: (160-162)
  • Experimental Methods Keywords

    Methodology:Acute hepatitis, Autoimmune haemolytic anemia, Chronic calcific pancreatitis, Inosine monophosphate dehydrogenase, Mycophenolate mofetil, Serum glutamic pyruvic transaminase
    Research Materials: patient

Keywords

Acute hepatitis Autoimmune haemolytic anemia Chronic calcific pancreatitis Inosine monophosphate dehydrogenase Mycophenolate mofetil Serum glutamic pyruvic transaminase

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