Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005321
Title: Efficacy of aspirin in cardiovascular system – A systemic review
Category: Pharmacology
Section: Review Article
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    Aspirin is a one size fits all drugs that have been used for a plethora of indications ranging from your day-to-day fever to osteoarthritis. This has been considered a magic drug by most of the researchers due to its multiailment curing properties. Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins (PGs) and TXA2. Aspirin’s ability to suppress the production of PGs and thromboxane is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. COX is required for PG and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. This makes aspirin different from other nonsteroidal anti-inflammatory drugs (such as diclofenac and ibuprofen), which are reversible inhibitors. However, still, concerns remain about its safety as it is also related with many cardiovascular and cerebrovascular events such as intracranial hemorrhage, ischemic stroke, continued bleeding, and some types of cancers like colorectal cancer in spite of its role in treating the same. Hence, this study aims at stating the drug’s efficacy and its various beneficial and harmful effects if any, that is, posed by the drug.

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    Author(s) Name:

    U. Ahamed Irshath*, Aathithyananththangavadivelu, Ramaiyan Velmurugan

    Affiliation(s) Name:

    Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: U. Ahamed Irshath, Department of ???, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Velan Nagar, P. V. Vaithiyalingam Road, Pallavaram, Chennai - 600117, Tamil Nadu, India

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    Author:

    U. Ahamed Irshath*, Aathithyananththangavadivelu, Ramaiyan Velmurugan

    Title:Efficacy of aspirin in cardiovascular system – A systemic review
    Journal:Drug Invention Today
    Vol(issue):13 (February )
    Year:2020
    Page No: (198-204)
  • Experimental Methods Keywords

    Methodology:Anticoagulants, Cardiovascular disease, Cardiovascular risk, Cerebral infarction, Hemorrhage, Ischemic stroke
    Research Materials:Aspirin

Keywords

Anticoagulants Cardiovascular disease Cardiovascular risk Cerebral infarction Hemorrhage Ischemic stroke

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