Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005400
Title: Phytochemical characterization and antioxidant properties of Punica granatum peel extract
Category: Pharmacology
Section: Research Article
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    Background: The pomegranate (Punica granatum) is a fruit-bearing deciduous shrub or small tree in the family Lythraceae. As intact arils or juice, pomegranates are used in baking, cooking, juice blends, meal garnishes, smoothies, and alcoholic beverages such as cocktails and wine. In India’s ancient Ayurveda system of traditional medicine, the pomegranate is frequently described as an ingredient in remedies. Materials and Methods: The peel from the fruit was removed carefully by knife and allowed to dry. The dried material was properly ground into powder and kept in refrigerator for further analysis. The peel powder was loaded into Soxhlet extractor and subjected to extraction with methanol. After extraction, the solvent was distilled off and the extracts were concentrated on water bath to a dry residue and kept in a desiccator. Phytochemical screening: Phytochemical screening of P. granatum peel ethanolic extracts was assessed by standard method. Results: 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity: In the present study, P. granatum peel ethanolic extract showed a significant increased the DPPH radical scavenging activity. However, the maximum inhibition was observed at 500 μg/ml equal to that of Vitamin C, a standard drug used in this study. As like DPPH radical scavenging activity, the extract showed a significant increased the nitric oxide (NO) radical scavenging activity. However, the maximum inhibition was observed at 500 μg/ml equal to that of Vitamin C, a standard drug used in this study. Conclusions: The in vitro studies on DPPH and NO radical scavenging study showed P. granatum peel extract has a strong dose-dependent free radical scavenging ability may be due to the presence of phytochemicals such as saponins terpenoids, steroids, flavonoids, phenols and alkaloids could have contributed for such antioxidant potentials. Hence, the present findings indicate that P. granatum may be used as potential antioxidant which may help for the treatment of various diseases.

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    Author(s) Name:

    G. Gokul 1 , V. Vishnpriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India,

    3 Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    G. Gokul 1 , V. Vishnpriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj1 *

    Title:Phytochemical characterization and antioxidant properties of Punica granatum peel extract
    Journal:Drug Invention Today
    Vol(issue):11 (December )
    Year:2019
    Page No: (3423-3426)
  • Experimental Methods Keywords

    Methodology:Antioxidant potential
    Research Materials:Punica grantum peel extract

Keywords

Punica grantum peel extract DPPH NO Antioxidant potential

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