Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005417
Title: Inhibitory effect of ethanolic leaf extract of Acacia etbaica schweinf on production of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 macrophage cells
Category: Pharmacology
Section: Research Article
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    Introduction: Acacia etbaica Schweinf is a medicinal plant belonging to family Fabaceae that has long been used in traditionally to treat stomach pain, swelling, livestock eye infection, itching, and fire burn. Objective: The objective of the study was to investigate the in vitro anti-inflammatory effect of ethanolic leaf extract of A. etbaica Schweinf in lipopolysaccharide (LPS)- induced RAW 264.7 macrophage cell lines. Materials and Methods: The ethanolic leaf extract of A. etbaica Schweinf was prepared and followed by to investigate the inhibitory effect on LPS -induced production of pro-inflammatory cytokines (interleukin-1β [IL]; IL-6; and tumor necrosis factor-α [TNF-α]) in RAW 264.7 cells were analyzed by sandwich enzyme- linked immunosorbent assay (ELISA) kit. Results: The ethanolic leaf extract of A. etbaica Schweinf was significantly decreased the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in a dose depended manner in LPS-stimulated RAW 264.7 cells. Conclusion: It can be concluded that the ethanolic leaf extract of A. etbaica Schweinf is a potential candidate for the development of anti-inflammatory agents for the treatment of inflammatory-related diseases.

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    Author(s) Name:

    T. Tekleweyni, H. Kidu, W. Tesfay, K. Krishna Chaithanya, Zenebe Hagos, V. K. Gopalakrishnan*

    Affiliation(s) Name:

    Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia

    *Corresponding author: Dr. V. K. Gopalakrishnan, Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Post Box No: 1010, Axum, Tigray Region, Ethiopia.

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    Author:

    T. Tekleweyni, H. Kidu, W. Tesfay, K. Krishna Chaithanya, Zenebe Hagos, V. K. Gopalakrishnan*

    Title:Inhibitory effect of ethanolic leaf extract of Acacia etbaica schweinf on production of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 macrophage cells
    Journal:Drug Invention Today
    Vol(issue):13 (March)
    Year:2020
    Page No: (151-154)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory, Interleukin-1β, Interleukin-6, Tumor necrosis factor-α
    Research Materials:Acacia etbaica Schweinf,

Keywords

Acacia etbaica Schweinf Anti-inflammatory Interleukin-1β Interleukin-6 Tumor necrosis factor-α

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