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Abstract

Background: One of the major risks during and after surgery is the perioperative blood loss, which significantly contributes to high death rate, post-operative complications, and usage of the health-care resources. Materials and Methods: This narrative review was based on a literature search of relevant databases up to December 2019, for publications relevant to reducing blood loss in various surgeries involving the drugs clonidine or metoprolol. Results: There are many suggested methods and techniques to reduce blood loss during major surgical procedures which broadly includes organizational, surgical, anesthetic, and hemostatic strategies. Hypotensive anesthesia produces promising results in reducing the intraoperative blood loss by lowering the blood pressure during surgery. Both clonidine and metoprolol potentiate the effect of hypotensive anesthesia and contribute to efficiently controlling the intraoperative hemorrhage. Both clonidine and metoprolol have proved its efficiency in various major surgeries such as spine surgery, gynecologic surgery, neurosurgery, and maxillofacial surgeries. Conclusion: Both clonidine and metoprolol show promising results in controlling blood loss during various surgical procedures. Although high-quality evidence exists in certain areas, the overall evidence base for reducing intraoperative blood loss with clonidine and metoprolol remains limited.

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	JPR Solutions

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