Journal: Drug Invention Today

Article Id: JPRS-P'Col-00005424
Title: Histopathological evaluation of the correlation of depth of invasion and the nodal metastasis – A pilot study in south indian population
Category: Pharmacology
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Introduction: Oral squamous cell carcinoma (OSCC) is unpredictable lesion and thus has a marked variation in prognosis, which is probably due to the function of many variables related to biological behaviors of primary lesion. Aim: The aim of the study was to find the correlation between the depth of invasion (DOI) and the nodal metastasis and to explore the risk of occult neck nodal metastasis and local recurrence in relation to depth in early stage squamous cell carcinoma of tongue. Materials and Methods: We have retrieved records of the OSCC patients retrospectively for the past 2 years. The DOI for 30 excision specimens was measured using the magna software. Measurement was done by experienced pathologists in millimeters. Results: In our study, we have found that DOI above 6 mm was established in 80% and developed nodal metastasis with 13.33% had recurrence. Conclusion: DOI is studied in a smaller number of Indian studies, but with the increase in the multifactorial etiology in the Indian population, we suggest that there is a discerning point at 5 mm of tumor depth at which cervical metastasis is probable. Therefore, the DOI is found to be an important prognostic marker in OSCC.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Sinduja Palati*, Pratibha Ramani, Herald. J. Sherlin, S. Gheena, Abilasha Ramasubramanian, K. R. Don, Gifrina Jayaraj

    Affiliation(s) Name:

    Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Sinduja Palati, Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University,, No. 162, Masilamani Nagar, Seneerkuppam Bypass Road, Poonamallee, Chennai, Tamil Nadu, India

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Sinduja Palati*, Pratibha Ramani, Herald. J. Sherlin, S. Gheena, Abilasha Ramasubramanian, K. R. Don, Gifrina Jayaraj

    Title:Histopathological evaluation of the correlation of depth of invasion and the nodal metastasis – A pilot study in south indian population
    Journal:Drug Invention Today
    Vol(issue):13 (March)
    Year:2020
    Page No: (185-188)
  • Experimental Methods Keywords

    Methodology:Oral cancer, Prognosis, Squamous cell carcinoma
    Research Materials:south indian population

Keywords

Depth of invasion Oral cancer Prognosis Squamous cell carcinoma

Our Services

Most Downloaded List