Journal: Drug Invention Today

Article Id: JPRS-MSNS-00005425
Title: Antibacterial activity of novel selenium and zinc nanoparticles toward oral Candida albicans: An In vitro study
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Introduction: For ages, man has tried to find a cure all panaceas for oral maladies caused by microorganisms. Toward this endeavor, many chemicals have been tried and tested, some were successful, but they all have certain side effects on long-term use. Phytotherapy is an emerging field to treat infectious diseases using plant-mediated products which is safe and has very limited side effects. Aim: Hence, we wanted to assess the antimicrobial potential of silver and zinc nanoparticles (ZnNPs) synthesized using Triphala against oral candidal organisms. Materials and Methods: Selenium and ZnNPs synthesized using green synthesis from Triphala were evaluated for its antimicrobial activity against Candida albicans isolated from oral cavity of individuals suffering from dental caries. Various concentrations of the NPs (25, 50, and 100 µl) were used to check the zone of inhibition. The efficacy was tested among 25 samples and data were analyzed using SPSS, V23. Results: The mean zone of inhibition for selenium NPs was 10 ± 1.8 mm, 15 ± 2.1 mm, and 31 ± 3.3 mm for 25, 50, and 100 µl concentrations. Similarly, ZnNPs had zone of inhibition of 9.7 ± 1.9 mm, 14 ± 2.8 mm, and 29.9 ± 2.7 mm for 25, 50, and 100 µl concentrations. No statistically significant difference was found between the two groups and both exhibited excellent antimicrobial efficacy against C. albicans. Conclusion: Selenium and ZnNPs synthesized from Triphala proved to be an excellent antimicrobial agent against oral C. albicans. This provides future scope to develop oral antimicrobials using these agents to prevent candidal infections of the oral cavity.

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    Author(s) Name:

    Ebtesam Khalil 1 , Issameldin Abdalla Elkhader2 , Nesrine A. Elsahn3 , Aicha Sid Ahmed4 , S. S. Raj5 *

    Affiliation(s) Name:

    1 Department of Surgical Science, College of Dentistry, Ajman University, Ajman, United Arab Emirates,

    2 Department of Basic Medical Science, College of Dentistry, Ajman University, Ajman, United Arab Emirates,

    3 Department of Restorative Dentistry, Ajman University, Ajman, United Arab Emirates,

    4 Department of Surgical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates,

    5 Department of Public Health Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. S. S. Raj, Department of Public Health Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    Ebtesam Khalil 1 , Issameldin Abdalla Elkhader2 , Nesrine A. Elsahn3 , Aicha Sid Ahmed4 , S. S. Raj5 *
    Title:Antibacterial activity of novel selenium and zinc nanoparticles toward oral Candida albicans: An In vitro study
    Journal:Drug Invention Today
    Vol(issue):14 (March)
    Year:2020
    Page No: (36-38)

  • Experimental Methods Keywords

    Methodology: Antimicrobial, Candida, Green synthesis
    Research Materials:Nanoparticles, Selenium, Zinc

Keywords

Antimicrobial Candida Green synthesis Nanoparticles Selenium Zinc

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